{"id":6805,"date":"2026-02-01T11:06:01","date_gmt":"2026-02-01T03:06:01","guid":{"rendered":"https:\/\/nullthought.net\/?p=6805"},"modified":"2026-02-01T11:06:03","modified_gmt":"2026-02-01T03:06:03","slug":"%e5%9f%ba%e4%ba%8e%e5%a4%9a%e6%99%ba%e8%83%bd%e4%bd%93%e7%be%a4%e4%bd%93%e5%8d%8f%e4%bd%9c%e7%9a%84%e8%9b%8b%e7%99%bd%e5%ba%8f%e5%88%97%e8%ae%be%e8%ae%a1","status":"publish","type":"post","link":"https:\/\/nullthought.net\/?p=6805","title":{"rendered":"\u57fa\u4e8e\u591a\u667a\u80fd\u4f53\u7fa4\u4f53\u534f\u4f5c\u7684\u86cb\u767d\u5e8f\u5217\u8bbe\u8ba1"},"content":{"rendered":"\n<p><strong>de novo\uff08\u4ece\u96f6\u5f00\u59cb\uff09\u86cb\u767d\u5e8f\u5217\u8bbe\u8ba1<\/strong>\u7684\u6838\u5fc3\u96be\u70b9\u5728\u4e8e\uff1a\u5e8f\u5217\u7a7a\u95f4\u6781\u5176\u5de8\u5927\uff0c\u800c\u4e14\u201c\u5e8f\u5217\u2014\u7ed3\u6784\u2014\u529f\u80fd\u201d\u4e4b\u95f4\u8026\u5408\u590d\u6742\u3002\u8bb8\u591a\u4e3b\u6d41\u751f\u6210\u65b9\u6cd5\uff08\u5982\u86cb\u767d\u8bed\u8a00\u6a21\u578b\u3001\u6269\u6563\u6a21\u578b\u7b49\uff09\u5f80\u5f80\u9700\u8981<strong>\u5fae\u8c03\u3001\u4efb\u52a1\u7279\u5b9a\u6570\u636e\u3001\u6216\u6a21\u578b\u7ed3\u6784\/\u6d41\u7a0b\u91cd\u914d\u7f6e<\/strong>\uff0c\u8fd9\u4f1a\u964d\u4f4e\u65b9\u6cd5\u7684\u7075\u6d3b\u6027\u4e0e\u53ef\u6269\u5c55\u6027\u3002\u4e3a\u6b64\uff0c\u8bba\u6587<strong><a href=\"https:\/\/arxiv.org\/abs\/2511.22311v1\" target=\"_blank\" rel=\"noreferrer noopener\">Swarms of Large Language Model Agents for Protein Sequence Design with Experimental Validation<\/a><\/strong>\u63d0\u51fa\u4e00\u79cd<strong>\u4e0d\u9700\u8981\u8bad\u7ec3\/\u5fae\u8c03<\/strong>\u3001\u80fd\u76f4\u63a5\u6309\u76ee\u6807\u505a\u201c\u5b9a\u5236\u5316\u8bbe\u8ba1\u201d\u7684\u65b0\u6846\u67b6\uff0c\u5e76\u7528\u5b9e\u9a8c\u505a\u4e86\u9a8c\u8bc1\u3002<\/p>\n\n\n\n<p>\u8bba\u6587\u4f5c\u8005\u4e3aFiona Y. Wang, Di Sheng Lee, David L. Kaplan, Markus J. Buehler\uff0c\u6765\u81eaMIT\u548cTufts University\u3002<\/p>\n\n\n\n<p>\u4f5c\u8005\u7684\u5173\u952e\u8bbe\u8ba1\u662f\uff1a\u628a\u86cb\u767d\u5e8f\u5217\u7684<strong>\u6bcf\u4e00\u4e2a\u6b8b\u57fa\u4f4d\u7f6e<\/strong>\u90fd\u4ea4\u7ed9\u4e00\u4e2a\u72ec\u7acb\u7684 LLM agent\uff08\u201cposition-wise agent\u201d\uff09\uff0c\u8ba9\u5b83\u53ea\u8d1f\u8d23\u51b3\u5b9a\u81ea\u5df1\u90a3\u4e00\u4f4d\u8be5\u53d8\u6210\u4ec0\u4e48\u6c28\u57fa\u9178\uff1b\u540c\u65f6\u6240\u6709 agent \u5171\u4eab\u540c\u4e00\u4e2a\u8bbe\u8ba1\u76ee\u6807\u4e0e\u201c\u5171\u4eab\u63a8\u7406\u67a2\u7ebd\/\u4fe1\u606f\u67a2\u7ebd\u201d\uff0c\u5e76\u5728\u6bcf\u8f6e\u8fed\u4ee3\u540e\u63a5\u6536\u8bc4\u4f30\u53cd\u9988\u4e0e\u8bb0\u5fc6\u4fe1\u606f\uff0c\u518d\u8fdb\u5165\u4e0b\u4e00\u8f6e\u3002\u6574\u4e2a\u7cfb\u7edf\u5f3a\u8c03\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u53bb\u4e2d\u5fc3\u5316<\/strong>\uff1a\u4e0d\u662f\u4e00\u4e2a\u6a21\u578b\u4ece\u5934\u5230\u5c3e\u4e00\u6b21\u6027\u751f\u6210\u5168\u5e8f\u5217\uff0c\u800c\u662f\u201c\u6bcf\u4e2a\u4f4d\u7f6e\u5404\u53f8\u5176\u804c\u201d\u3002<\/li>\n\n\n\n<li><strong>\u5728\u7ebf\u7279\u5316<\/strong>\uff1a\u4e0d\u66f4\u65b0\u6a21\u578b\u6743\u91cd\uff0c\u800c\u662f\u5728\u63d0\u793a\u8bcd\u4e2d\u6ce8\u5165\u5c40\u90e8\u7ed3\u6784\/\u90bb\u57df\/\u5386\u53f2\u7b49\u4fe1\u606f\uff0c\u8ba9 agent \u5f53\u573a\u201c\u4e34\u65f6\u4e13\u7cbe\u201d\u3002<\/li>\n\n\n\n<li><strong>\u6d8c\u73b0\u5f0f\u8bbe\u8ba1<\/strong>\uff1a\u5168\u5c40\u7ed3\u6784\u4e0e\u529f\u80fd\u76ee\u6807\u901a\u8fc7\u8bb8\u591a\u5c40\u90e8\u51b3\u7b56\u7684\u534f\u540c\u9010\u6b65\u6d8c\u73b0\u51fa\u6765\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u8bba\u6587\u5bf9\u6bd4\u4e86\u8fd9\u79cd swarm \u6846\u67b6\u4e0e\u201c\u5355\u4f53\u6a21\u578b\u7ebf\u6027\u63a8\u7406\u201d\u7684\u5dee\u5f02\uff0c\u5e76\u660e\u786e\u7ed9\u51fa\u4e86 agent \u63d0\u793a\u8bcd\u5305\u542b\u7684\u56db\u7c7b\u4fe1\u606f\uff1a\u89d2\u8272\u4efb\u52a1\u4e0e\u89c4\u5219\u3001\u5c40\u90e8\u90bb\u57df\u4e0e\u7ed3\u6784\u4e0a\u4e0b\u6587\u3001\u76ee\u6807\u4e0e\u80fd\u91cf\u8d8b\u52bf\u3001\u4ee5\u53ca\u5168\u5c40\/\u5c40\u90e8\u8bb0\u5fc6\u5386\u53f2\uff1b\u8f93\u51fa\u5219\u662f\u201c\u7406\u7531 + \u5efa\u8bae\u6c28\u57fa\u9178\u201d\u3002<\/p>\n\n\n\n<p>\u8bba\u6587\u628a\u4e00\u6b21\u8fed\u4ee3\u62c6\u6210\u6e05\u6670\u7684\u56db\u9636\u6bb5\u5faa\u73af\uff08\u8fd9\u6837\u505a\u4e5f\u4fbf\u4e8e\u7f13\u5b58\/\u52a0\u901f\u3001\u907f\u514d\u201c\u8fb9\u63d0\u6848\u8fb9\u6298\u53e0\u201d\u7684\u6df7\u4e71\uff09\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u6536\u96c6\u63d0\u6848<\/strong>\uff1a\u6240\u6709\u4f4d\u7f6e agent \u5e76\u884c\u7ed9\u51fa\u201c\u8be5\u4f4d\u70b9\u4ece\u5f53\u524d\u6c28\u57fa\u9178\u2192\u65b0\u6c28\u57fa\u9178\u201d\u7684\u5efa\u8bae\uff08\u8fd9\u4e00\u9636\u6bb5\u4e0d\u505a\u7ed3\u6784\u8ba1\u7b97\uff09\u3002<\/li>\n\n\n\n<li><strong>\u5e94\u7528\u53d8\u66f4\u5e76\u6298\u53e0<\/strong>\uff1a\u628a\u6240\u6709\u4f4d\u70b9\u5efa\u8bae\u62fc\u6210\u65b0\u5e8f\u5217\uff0c\u7136\u540e\u7528\u7ed3\u6784\u9884\u6d4b\u5668\u628a\u5e8f\u5217\u6298\u53e0\u6210\u7ed3\u6784\uff08\u6587\u4e2d\u7528\u7684\u662f <strong>OmegaFold<\/strong>\uff09\u3002<\/li>\n\n\n\n<li><strong>\u7ed3\u6784\/\u76ee\u6807\u8bc4\u4f30<\/strong>\uff1a\u7528 <strong>Rosetta<\/strong> \u505a\u80fd\u91cf\u6253\u5206\u3001\u7528 <strong>DSSP<\/strong> \u505a\u4e8c\u7ea7\u7ed3\u6784\u6807\u6ce8\uff0c\u5e76\u8ba1\u7b97\u4e0e\u76ee\u6807\u76f8\u5173\u7684\u5b9a\u5236\u8bc4\u5206\u3002<\/li>\n\n\n\n<li><strong>\u63a5\u53d7\/\u62d2\u7edd + \u8bb0\u5fc6\u66f4\u65b0<\/strong>\uff1a\u5982\u679c\u65b0\u5e8f\u5217\u8ba9\u76ee\u6807\u8bc4\u5206\u66f4\u597d\uff0c\u6216\u5728\u76ee\u6807\u4e0d\u660e\u663e\u53d8\u5dee\u65f6\u80fd\u91cf\u66f4\u4f4e\uff0c\u5219\u63a5\u53d7\uff1b\u5426\u5219\u62d2\u7edd\u5e76\u8bb0\u5f55\u5931\u8d25\u5c1d\u8bd5\u3002<\/li>\n<\/ol>\n\n\n\n<p>\u4f5c\u8005\u663e\u5f0f\u505a\u4e86\u4e24\u5c42\u8bb0\u5fc6\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u5168\u5c40\u8bb0\u5fc6<\/strong>\uff1a\u8bb0\u5f55\u54ea\u4e9b\u5e8f\u5217\u88ab\u63a5\u53d7\/\u62d2\u7edd\u3001\u54ea\u4e9b\u7a81\u53d8\u6a21\u5f0f\u66f4\u53ef\u80fd\u6210\u529f\u3001\u80fd\u91cf\u4e0e\u7ed3\u6784\u5206\u6570\u7684\u8d8b\u52bf\u7b49\u3002<\/li>\n\n\n\n<li><strong>\u5c40\u90e8\u5386\u53f2<\/strong>\uff1a\u6bcf\u4e2a agent \u8bb0\u5f55\u81ea\u5df1\u4f4d\u70b9\u4e0a\u54ea\u4e9b\u66ff\u6362\u66f4\u6709\u6548\u3001\u4e0e\u90bb\u4f4d\u70b9\u7684\u4ea4\u4e92\u6548\u5e94\u3001\u4e0a\u4e0b\u6587\u4f9d\u8d56\u7684\u6210\u529f\u6a21\u5f0f\u7b49\u3002<br>\u8fd9\u4e9b\u8bb0\u5fc6\u4f1a\u88ab\u6574\u7406\u6210\u201c\u53ef\u5582\u7ed9 agent \u7684\u4e0a\u4e0b\u6587\u201d\uff0c\u7528\u4e8e\u4e0b\u4e00\u8f6e\u51b3\u7b56\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u76f4\u89c2\u4e0a\uff0c\u8fd9\u76f8\u5f53\u4e8e\u628a\u201c\u641c\u7d22\u8fc7\u7a0b\u4e2d\u7684\u7ecf\u9a8c\u201d\u7ed3\u6784\u5316\u6c89\u6dc0\u4e0b\u6765\uff0c\u8ba9 swarm \u4e0d\u53ea\u662f\u968f\u673a\u6e38\u8d70\uff0c\u800c\u662f\u9010\u6e10\u5b66\u4f1a\u54ea\u4e9b\u65b9\u5411\u66f4\u503c\u5f97\u63a2\u7d22\u3002<\/p>\n\n\n\n<p>\u8bba\u6587\u5c55\u793a\u4e86 4 \u7c7b\u7ed3\u6784\u76ee\u6807\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8ba9\u5e8f\u5217\u5f62\u6210 <strong>\u03b1-\u87ba\u65cb<\/strong>\uff08\u4e24\u79cd\u4e0d\u540c\u7ea6\u675f\uff1a\u504f\u4eb2\u6c34\u7684\u87ba\u65cb vs \u91cd\u590d\u7684 A\/L\/E \u6a21\u5f0f\uff09<\/li>\n\n\n\n<li>\u5f62\u6210 <strong>\u03b2-\u94fe\/\u03b2-\u7247\u5c42\u503e\u5411<\/strong>\uff08\u901a\u8fc7\u758f\u6c34\/\u6781\u6027\u4ea4\u66ff\uff09<\/li>\n\n\n\n<li>\u5f62\u6210 <strong>\u677e\u6563 coil\/\u65e0\u89c4\u5377\u66f2<\/strong>\uff08\u901a\u8fc7\u66f4\u591a\u5e26\u7535\u548c\u6781\u6027\u6b8b\u57fa\u51cf\u5c11\u7d27\u81f4\u6298\u53e0\uff09<br>\u5e76\u4e14\u7ed9\u51fa\u201c\u8d77\u59cb\u5e8f\u5217\u2192\u6700\u4f73\u5e8f\u5217\u2192\u9884\u6d4b\u4e09\u7ef4\u7ed3\u6784\u2192\u5e8f\u5217 logo\uff08\u6b8b\u57fa\u504f\u597d\uff09\u201d\u7684\u4e00\u6574\u5957\u8bc1\u636e\u94fe\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4f5c\u8005\u9009\u4e86\u4e24\u4e2a\u6613\u5408\u6210\u7684\u77ed\u80bd\u505a <strong>\u5706\u4e8c\u8272\u8c31\uff08CD\uff09<\/strong>\uff1a\u4e00\u4e2a\u662f\u4eb2\u6c34\u87ba\u65cb\u5e8f\u5217\u3001\u4e00\u4e2a\u662f coil \u5e8f\u5217\u3002\u7ed3\u679c\u663e\u793a\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u87ba\u65cb\u6837\u54c1\u51fa\u73b0\u5178\u578b\u7684 <strong>208\/222 nm \u53cc\u8c37<\/strong>\uff08\u03b1-\u87ba\u65cb\u7279\u5f81\u8c31\uff09\uff0c\u5e76\u7ed9\u51fa <strong>91.3% helix content<\/strong> \u7684\u4f30\u8ba1\uff1b<\/li>\n\n\n\n<li>coil \u6837\u54c1\u5728 210 nm \u4ee5\u4e0a\u692d\u5706\u5ea6\u5f88\u4f4e\uff0c\u4e14\u5728 <strong>195 nm \u9644\u8fd1\u8d1f\u5cf0<\/strong>\uff08\u65e0\u89c4\u5377\u66f2\u7279\u5f81\uff09\uff0c\u7ed9\u51fa <strong>58.9% coil content<\/strong>\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u8fd9\u90e8\u5206\u5f88\u91cd\u8981\uff1a\u5b83\u628a\u201cLLM+\u8bc4\u4f30\u201d\u4ea7\u751f\u7684\u5e8f\u5217\uff0c\u81f3\u5c11\u5728\u4e8c\u7ea7\u7ed3\u6784\u5c42\u9762\uff0c\u62c9\u5230\u4e86<strong>\u53ef\u5b9e\u9a8c\u590d\u73b0<\/strong>\u7684\u7a0b\u5ea6\u3002<\/p>\n\n\n\n<p>\u8bba\u6587\u7528\u201cRosetta \u80fd\u91cf\uff08\u7269\u7406\u53ef\u884c\u6027\uff09\u201d\u548c\u201c\u7ed3\u6784\/\u76ee\u6807\u5206\u6570\uff08\u662f\u5426\u7b26\u5408\u76ee\u6807\uff09\u201d\u8ddf\u8e2a 64 \u8f6e\u8fed\u4ee3\uff0c\u89c2\u5bdf\u5230\u4e00\u79cd\u5f88\u50cf\u542f\u53d1\u5f0f\u641c\u7d22\u7684\u6a21\u5f0f\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u65e9\u671f\u8fc5\u901f\u628a\u7ed3\u6784\u5206\u6570\u63a8\u5230\u8f83\u9ad8\u6c34\u5e73\u5e76\u964d\u4f4e\u80fd\u91cf\uff1b<\/li>\n\n\n\n<li>\u540e\u671f\u5728\u4fdd\u6301\u76ee\u6807\u7ed3\u6784\u4e0d\u88ab\u7834\u574f\u7684\u524d\u63d0\u4e0b\uff0c\u7ee7\u7eed\u63a2\u7d22\u66f4\u4f4e\u80fd\u91cf\u6216\u66f4\u4f18\u89e3\uff1b<\/li>\n\n\n\n<li>\u6574\u4f53\u5448\u73b0\u591a\u8f6e\u201c\u5148\u6536\u655b\u3001\u518d\u63a2\u7d22\u3001\u518d\u6536\u655b\u201d\u7684\u6446\u52a8\uff0c\u800c\u4e0d\u662f\u4e00\u6b21\u6027\u5355\u8c03\u6536\u655b\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4f5c\u8005\u5c55\u793a\u4e86\u4e09\u7c7b\u66f4\u201c\u529f\u80fd\u5bfc\u5411\u201d\u7684\u76ee\u6807\u80fd\u529b\uff1a<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>\u5339\u914d\u76ee\u6807\u632f\u52a8\u9891\u8c31\u5206\u5e03<\/strong>\uff1a\u8bbe\u8ba1\u7684\u86cb\u767d\u4f4e\u9891\u6a21\u6001\u5206\u5e03\u4e0e\u76ee\u6807\u9ad8\u5ea6\u4e00\u81f4\uff0c\u7ed9\u51fa cosine similarity <strong>0.991<\/strong>\uff08\u51e0\u4e4e\u5b8c\u7f8e\u5339\u914d\uff09\u3002<\/li>\n\n\n\n<li><strong>\u91d1\u5c5e\u7ed3\u5408\u53e3\u888b\/\u57fa\u5e8f<\/strong>\uff1a\u4ece \u03b2-hairpin \u51fa\u53d1\uff0c\u901a\u8fc7\u5f15\u5165 His\/Cys\/Met \u7b49\u6b8b\u57fa\u5f62\u6210\u914d\u4f4d\u53e3\u888b\uff1b\u5e8f\u5217 logo \u8fd8\u80fd\u201c\u81ea\u5df1\u201d\u6d8c\u73b0\u51fa\u7c7b\u4f3c <strong>CXXC<\/strong> \u7684\u5e38\u89c1\u91d1\u5c5e\u7ed3\u5408\u6a21\u5f0f\uff08\u4f5c\u8005\u5f3a\u8c03\u4e0d\u9700\u8981\u989d\u5916\u77e5\u8bc6\u8f93\u5165\uff09\u3002<\/li>\n\n\n\n<li><strong>\u591a\u7ed3\u6784\u57df\u8bbe\u8ba1<\/strong>\uff1a\u628a\u201cN \u7aef \u03b2\u3001C \u7aef \u03b1\u201d\u7684\u8d77\u59cb\u6784\u578b\uff0c\u8f6c\u6362\u4e3a\u201cN \u7aef \u03b1\u3001C \u7aef \u03b2\u201d\uff0c\u5e76\u5c55\u793a\u80fd\u5904\u7406\u66f4\u957f\u7684\u5e8f\u5217\uff08\u4f8b\u5b50\u91cc\u5230 <strong>136 residues<\/strong>\uff09\u3002<\/li>\n<\/ol>\n\n\n\n<p>\u540c\u65f6\u8bba\u6587\u8fdb\u4e00\u6b65\u8bf4\u660e\u5728\u9891\u8c31\u76ee\u6807\u4e0a\u4e5f\u4f1a\u51fa\u73b0\u6536\u655b\/\u63a2\u7d22\u4ea4\u66ff\uff1a\u63a2\u7d22\u9636\u6bb5\u80fd\u91cf\u4e0e\u9891\u8c31\u5206\u6570\u6ce2\u52a8\u66f4\u5927\uff0c\u6536\u655b\u9636\u6bb5\u5219\u66f4\u7a33\u5b9a\u3002<\/p>\n\n\n\n<p>\u8bba\u6587\u5728\u540c\u4e00\u4e2a\u201c\u5c40\u90e8\u5bf9\u79f0\u201d\u76ee\u6807\u4e0b\uff0c\u5bf9\u6bd4\u4e86 6 \u4e2a\u6a21\u578b\uff08grok-3-mini\u3001GPT-4o-mini\u3001Mistral-8B\u3001GPT-4.1\u3001GPT-4o\u3001Llama-3.2-3B\uff09\uff0c\u7528\u4e24\u79cd\u56fe\u6765\u523b\u753b\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Hamming \u8ddd\u79bb\u70ed\u56fe<\/strong>\uff1a\u770b\u5e8f\u5217\u5728\u5404\u8f6e\u4e4b\u95f4\u662f\u5426\u5feb\u901f\u53d8\u5f97\u76f8\u4f3c\uff08\u5f3a\u6536\u655b\uff09<\/li>\n\n\n\n<li><strong>UMAP \u6295\u5f71<\/strong>\uff1a\u770b\u7406\u5316\u6027\u8d28\u7a7a\u95f4\u4e2d\u63a2\u7d22\u7684\u8303\u56f4\u4e0e\u805a\u7c7b\u7ed3\u6784<\/li>\n<\/ul>\n\n\n\n<p>\u7ed3\u8bba\u662f\uff1a\u6709\u7684\u6a21\u578b\u66f4\u5feb\u6536\u655b\uff08\u591a\u6837\u6027\u8fc5\u901f\u584c\u7f29\uff09\uff0c\u6709\u7684\u6a21\u578b\u66f4\u201c\u53d1\u6563\u201d\u63a2\u7d22\uff08\u591a\u6837\u6027\u6301\u7eed\u66f4\u4e45\uff09\uff0c\u4ece\u800c\u5f71\u54cd swarm \u5728\u201c\u5feb\u901f\u627e\u5230\u53ef\u884c\u89e3\u201d\u4e0e\u201c\u66f4\u5e7f\u6cdb\u63a2\u7d22\u65b0\u89e3\u201d\u4e4b\u95f4\u7684\u5e73\u8861\u3002<\/p>\n\n\n\n<p>\u8bba\u6587\u7ed9\u4e86\u4e00\u4e2a\u6e05\u6670\u5b9a\u4f4d\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7ed3\u6784\u9884\u6d4b\u6a21\u578b\uff1a\u66f4\u504f\u201c\u9884\u6d4b\u201d\uff0c\u7a81\u53d8\u4e0d\u591f\u201c\u61c2\u76ee\u6807\u201d\uff1b<\/li>\n\n\n\n<li>\u81ea\u56de\u5f52\u86cb\u767d\u8bed\u8a00\u6a21\u578b\uff1a\u751f\u6210\u80fd\u529b\u5f3a\uff0c\u4f46\u5bf9\u81ea\u5b9a\u4e49\u89c4\u5219\/\u76ee\u6807\u7684\u53ef\u63a7\u6027\u6709\u9650\uff1b<\/li>\n\n\n\n<li>\u6269\u6563\u6a21\u578b\uff1a\u53ef\u505a\u8bbe\u8ba1\u4f46\u591a\u76ee\u6807\/\u89c4\u5219\u5316\u63a7\u5236\u66f4\u590d\u6742\uff1b<\/li>\n\n\n\n<li>swarm\uff1a\u5f3a\u8c03 <strong>\u66f4\u9ad8\u7684\u8bbe\u8ba1\u81ea\u7531\u5ea6<\/strong>\u3001\u80fd\u201c\u6709\u6839\u636e\u5730\u201d\u505a\u7a81\u53d8\u3001\u80fd\u9075\u5b88\u81ea\u5b9a\u4e49\u89c4\u5219\u3001\u80fd\u505a\u591a\u76ee\u6807\u4f18\u5316\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u4f5c\u8005\u628a swarm \u751f\u6210\u5e8f\u5217\u3001\u5929\u7136\u86cb\u767d\u6570\u636e\u5e93\uff08SCOPe\uff09\u5e8f\u5217\u3001\u4ee5\u53ca ProteinMPNN \u751f\u6210\u5e8f\u5217\u653e\u5728\u540c\u4e00\u4e2a\u201c\u6570\u503c\u7279\u5f81\u7a7a\u95f4\u201d\u91cc\u6bd4\u8f83\uff1a\u7279\u5f81\u5305\u62ec 20 \u79cd\u6c28\u57fa\u9178\u7ec4\u6210\u9891\u7387 + \u5206\u5b50\u91cf\/\u82b3\u9999\u6027\u7b49\u7406\u5316\u6307\u6807\uff1b\u7136\u540e\u7528 t-SNE \u505a 2D \u53ef\u89c6\u5316\u3001\u7528 neighbor-joining \u505a\u6811\u72b6\u5173\u7cfb\u56fe\u3002<\/p>\n\n\n\n<p>\u7ed3\u679c\u663e\u793a\uff1aswarm \u751f\u6210\u5e8f\u5217\u4e2d\u65e2\u6709\u9760\u8fd1\u201c\u5929\u7136\u6837\u201d\u533a\u57df\u7684\uff0c\u4e5f\u6709\u63a5\u8fd1 ProteinMPNN \u98ce\u683c\u7684\uff0c\u8fd8\u6709\u4e00\u90e8\u5206\u843d\u5728\u4e24\u8005\u90fd\u8f83\u5c11\u8986\u76d6\u7684\u533a\u57df\uff0c\u8bf4\u660e\u5b83\u80fd\u5728\u201c\u5408\u7406\u6027\u201d\u548c\u201c\u65b0\u9896\u6027\u201d\u4e4b\u95f4\u505a\u51fa\u4e00\u5b9a\u5e73\u8861\u3002<\/p>\n\n\n\n<p>\u8bba\u6587\u628a\u8bad\u7ec3\u6210\u672c\u4e0e\u63a8\u7406\u6210\u672c\u653e\u5728\u4e00\u8d77\u5bf9\u6bd4\uff1aAlphaFold\u3001ProtGPT2\u3001ESM2\u3001RFdiffusion\u3001ProteinMPNN \u7b49\u90fd\u6709\u663e\u8457\u7684\u9884\u8bad\u7ec3\/\u8bad\u7ec3\u5f00\u9500\uff1b\u800c swarm <strong>\u4e0d\u9700\u8981\u8bad\u7ec3<\/strong>\uff0c\u5b8c\u6210\u4e00\u6b21\u5b8c\u6574\u8fed\u4ee3\u5f0f\u8bbe\u8ba1\u5927\u7ea6\u662f\u201c\u5c11\u91cf GPU \u5c0f\u65f6\u201d\uff0c\u603b\u4f53\u8017\u65f6\u66f4\u53d7 LLM API \u54cd\u5e94\u65f6\u95f4\u5f71\u54cd\u3002<\/p>\n\n\n\n<p><strong>\u4f5c\u8005\u603b\u7ed3\u7684\u8d21\u732e<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7528\u201c\u6bcf\u4f4d\u70b9\u4e00\u4e2a agent\u201d\u7684 swarm \u601d\u8def\uff0c\u5b9e\u73b0\u591a\u79cd\u7ed3\u6784\u76ee\u6807\uff08\u03b1\/\u03b2\/coil\uff09\u5e76\u505a\u4e86 CD \u5b9e\u9a8c\u9a8c\u8bc1\uff1b<\/li>\n\n\n\n<li>\u80fd\u505a\u66f4\u590d\u6742\u7684\u529f\u80fd\/\u7269\u6027\u76ee\u6807\uff08\u9891\u8c31\u3001\u91d1\u5c5e\u53e3\u888b\u3001\u591a\u57df\u7ed3\u6784\uff09\uff1b<\/li>\n\n\n\n<li>\u901a\u8fc7\u9009\u62e9\u4e0d\u540c\u5e95\u5c42 LLM \u8c03\u8282\u63a2\u7d22\/\u6536\u655b\u884c\u4e3a\uff1b<\/li>\n\n\n\n<li>\u5bf9\u6807\u591a\u7c7b\u4e3b\u6d41\u65b9\u6cd5\uff0c\u5f3a\u8c03\u53ef\u63a7\u3001\u591a\u76ee\u6807\u4e0e\u65e0\u9700\u8bad\u7ec3\uff1b<\/li>\n\n\n\n<li>\u4ea7\u751f\u5e8f\u5217\u8986\u76d6\u5929\u7136\u6837\u4e0e\u65b0\u533a\u57df\uff1b\u6574\u4f53\u8ba1\u7b97\u5f00\u9500\u4f4e\u3002<\/li>\n<\/ul>\n\n\n\n<p><strong>\u4ece\u65b9\u6cd5\u8bbe\u5b9a\u51fa\u53d1\u53ef\u4ee5\u9884\u671f\u7684\u5c40\u9650\uff08\u8bba\u6587\u91cc\u4e5f\u80fd\u770b\u5230\u4e00\u4e9b\u201c\u6697\u793a\u201d\uff09<\/strong>\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5f3a\u4f9d\u8d56\u201c\u8bc4\u4f30\u5668\u94fe\u8def\u201d\uff08\u7ed3\u6784\u9884\u6d4b + Rosetta + \u76ee\u6807\u8bc4\u5206\uff09\u3002\u5982\u679c\u8bc4\u4f30\u5668\u504f\u5dee\u8f83\u5927\uff0cswarm \u53ef\u80fd\u4f1a\u88ab\u5e26\u504f\uff08\u8fd9\u662f\u6240\u6709\u201c\u751f\u6210+\u8bc4\u4f30\u201d\u8303\u5f0f\u7684\u5171\u540c\u98ce\u9669\uff09\u3002<\/li>\n\n\n\n<li>\u66f4\u957f\u5e8f\u5217\/\u66f4\u590d\u6742\u529f\u80fd\u7684\u5b9e\u9a8c\u9a8c\u8bc1\u8fd8\u5f88\u6709\u9650\uff1a\u672c\u6587\u5b9e\u9a8c\u4e3b\u8981\u9a8c\u8bc1\u4e86\u4e8c\u7ea7\u7ed3\u6784\u53ef\u590d\u73b0\uff1b\u66f4\u9ad8\u9636\u529f\u80fd\u4ecd\u4e3b\u8981\u662f\u8ba1\u7b97\u8bc1\u636e\u3002<\/li>\n\n\n\n<li>\u8fd0\u884c\u65f6\u95f4\u53ef\u80fd\u88ab LLM \u63a8\u7406\/\u8c03\u7528\u5f00\u9500\u4e3b\u5bfc\uff08\u4f5c\u8005\u4e5f\u63d0\u5230\u603b\u8017\u65f6\u4e3b\u8981\u7531 API \u54cd\u5e94\u51b3\u5b9a\uff09\u3002<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>de novo\uff08\u4ece\u96f6\u5f00\u59cb\uff09\u86cb\u767d\u5e8f\u5217\u8bbe\u8ba1\u7684\u6838\u5fc3\u96be\u70b9\u5728\u4e8e\uff1a\u5e8f\u5217\u7a7a\u95f4\u6781\u5176\u5de8\u5927\uff0c\u800c\u4e14\u201c\u5e8f\u5217\u2014\u7ed3\u6784\u2014\u529f\u80fd\u201d\u4e4b\u95f4\u8026\u5408\u590d\u6742\u3002 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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novo\uff08\u4ece\u96f6\u5f00\u59cb\uff09\u86cb\u767d\u5e8f\u5217\u8bbe\u8ba1\u7684\u6838\u5fc3\u96be\u70b9\u5728\u4e8e\uff1a\u5e8f\u5217\u7a7a\u95f4\u6781\u5176\u5de8\u5927\uff0c\u800c\u4e14\u201c\u5e8f\u5217\u2014\u7ed3\u6784\u2014\u529f\u80fd\u201d\u4e4b\u95f4\u8026\u5408\u590d\u6742\u3002&hellip;","_links":{"self":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts\/6805","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6805"}],"version-history":[{"count":1,"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts\/6805\/revisions"}],"predecessor-version":[{"id":6806,"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts\/6805\/revisions\/6806"}],"wp:attachment":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6805"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6805"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6805"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}