{"id":6069,"date":"2025-07-12T11:31:38","date_gmt":"2025-07-12T03:31:38","guid":{"rendered":"https:\/\/nullthought.net\/?p=6069"},"modified":"2025-07-12T11:31:40","modified_gmt":"2025-07-12T03:31:40","slug":"chemeleon%ef%bc%9a%e5%9f%ba%e4%ba%8e%e5%88%86%e5%ad%90%e6%8f%8f%e8%bf%b0%e7%ac%a6%ef%bc%8c%e5%8f%af%e5%bf%ab%e9%80%9f%e5%87%86%e7%a1%ae%e9%a2%84%e6%b5%8b%e5%88%86%e5%ad%90%e6%80%a7%e8%b4%a8%e7%9a%84","status":"publish","type":"post","link":"https:\/\/nullthought.net\/?p=6069","title":{"rendered":"CheMeleon\uff1a\u57fa\u4e8e\u5206\u5b50\u63cf\u8ff0\u7b26\uff0c\u53ef\u5feb\u901f\u51c6\u786e\u9884\u6d4b\u5206\u5b50\u6027\u8d28\u7684\u521b\u65b0\u6a21\u578b"},"content":{"rendered":"\n

\u4f7f\u7528\u673a\u5668\u5b66\u4e60\u5feb\u901f\u4e14\u51c6\u786e\u5730\u9884\u6d4b\u5206\u5b50\u6027\u8d28\uff0c\u5bf9\u4e8e\u591a\u4e2a\u79d1\u5b66\u9886\u57df\u7684\u8fdb\u6b65\u5177\u6709\u5173\u952e\u610f\u4e49\u3002\u5c24\u5176\u662f\u57fa\u7840\u6a21\u578b\uff08Foundation Models\uff09\u5df2\u88ab\u8bc1\u660e\u6781\u4e3a\u6709\u6548\uff0c\u80fd\u591f\u5728\u5c0f\u89c4\u6a21\u3001\u771f\u5b9e\u4e16\u754c\u6570\u636e\u96c6\u4e0a\u5b9e\u73b0\u9ad8\u7cbe\u5ea6\u8bad\u7ec3\u3002\u8bba\u6587Descriptor-based Foundation Models for Molecular Property Prediction<\/a><\/strong>\u63d0\u51fa\u4e86\u4e00\u79cd\u65b0\u9896\u7684\u5206\u5b50\u57fa\u7840\u6a21\u578b CheMeleon<\/strong>\uff0c\u8be5\u6a21\u578b\u5728 Mordred \u8f6f\u4ef6\u5305<\/strong>\u4e2d\u8ba1\u7b97\u5f97\u5230\u7684\u786e\u5b9a\u6027\u5206\u5b50\u63cf\u8ff0\u7b26\u4e0a\u8fdb\u884c\u9884\u8bad\u7ec3\uff0c\u91c7\u7528 \u6709\u5411\u6d88\u606f\u4f20\u9012\u795e\u7ecf\u7f51\u7edc\uff08Directed Message-Passing Neural Network, D-MPNN\uff09<\/strong> \u5728\u65e0\u566a\u58f0\u73af\u5883\u4e0b\u9884\u6d4b\u8fd9\u4e9b\u63cf\u8ff0\u7b26\u3002\u4e0e\u4f20\u7edf\u4f9d\u8d56\u4e8e\u566a\u58f0\u8f83\u5927\u7684\u5b9e\u9a8c\u6570\u636e\u6216\u5b58\u5728\u504f\u5dee\u7684\u91cf\u5b50\u5316\u5b66\u6a21\u62df\u7684\u65b9\u5f0f\u4e0d\u540c\uff0cCheMeleon \u5229\u7528\u4f4e\u566a\u58f0\u7684\u5206\u5b50\u63cf\u8ff0\u7b26\u6765\u5b66\u4e60\u4e30\u5bcc\u7684\u5206\u5b50\u8868\u793a\u3002\u5728 Polaris \u548c MoleculeACE<\/strong> \u63d0\u4f9b\u7684 58 \u4e2a\u57fa\u51c6\u6570\u636e\u96c6<\/strong>\u4e0a\u8bc4\u4f30\u7ed3\u679c\u663e\u793a\uff0cCheMeleon \u5728 Polaris \u4efb\u52a1\u4e2d\u8fbe\u5230 79% \u7684\u80dc\u7387<\/strong>\uff0c\u8d85\u8d8a\u4e86 Random Forest\uff0846%\uff09\u3001fastprop\uff0839%\uff09\u548c Chemprop\uff0836%\uff09\u7b49\u57fa\u7ebf\u6a21\u578b\uff1b\u5728 MoleculeACE \u6d3b\u6027\u6d4b\u5b9a\u4e2d\u66f4\u662f\u53d6\u5f97 97% \u7684\u80dc\u7387<\/strong>\uff0c\u663e\u8457\u4f18\u4e8e Random Forest\uff0863%\uff09\u4ee5\u53ca\u5176\u4ed6\u57fa\u7840\u6a21\u578b\u3002\u4e0d\u8fc7\uff0cCheMeleon \u548c\u5176\u4ed6\u88ab\u6d4b\u8bd5\u6a21\u578b\u4e00\u6837\uff0c\u5728\u8bc6\u522b\u201c\u6d3b\u6027\u60ac\u5d16\uff08activity cliffs\uff09\u201d\u65b9\u9762\u4ecd\u7136\u5b58\u5728\u56f0\u96be\u3002\u5bf9 CheMeleon \u5b66\u4e60\u5230\u7684\u8868\u793a\u8fdb\u884c t-SNE \u964d\u7ef4\u6295\u5f71\u540e\u663e\u793a\uff0c\u5176\u5728\u5316\u5b66\u7cfb\u5217\u7684\u533a\u5206\u4e0a\u5177\u6709\u826f\u597d\u7684\u6548\u679c\uff0c\u7a81\u663e\u4e86\u5176\u6355\u6349\u5206\u5b50\u7ed3\u6784\u7ec6\u5fae\u5dee\u5f02\u7684\u80fd\u529b\u3002\u8fd9\u4e9b\u7ed3\u679c\u5f3a\u8c03\u4e86\u57fa\u4e8e\u63cf\u8ff0\u7b26\u7684\u9884\u8bad\u7ec3\u7b56\u7565\u5728\u5b9e\u73b0\u53ef\u6269\u5c55\u4e14\u9ad8\u6548\u7684\u5206\u5b50\u6027\u8d28\u9884\u6d4b\u4e2d\u7684\u6f5c\u529b\uff0c\u5e76\u4e3a\u4eca\u540e\u8fdb\u4e00\u6b65\u63a2\u7d22\u63cf\u8ff0\u7b26\u96c6\u5408\u4e0e\u65e0\u6807\u6ce8\u6570\u636e\u96c6\u63d0\u4f9b\u4e86\u5e7f\u9614\u7684\u7814\u7a76\u65b9\u5411\u3002<\/p>\n\n\n\n

\u8bba\u6587\u4f5c\u8005\u4e3aJackson Burns, Akshat Zalte, William Green\uff0c\u5747\u6765\u81eaMIT\u3002<\/p>\n\n\n\n

\u4e00\u3001\u7814\u7a76\u80cc\u666f\u4e0e\u95ee\u9898\u52a8\u673a
\u5728\u836f\u7269\u53d1\u73b0\u3001\u6750\u6599\u8bbe\u8ba1\u548c\u50ac\u5316\u5242\u5f00\u53d1\u7b49\u9886\u57df\u4e2d\uff0c\u5feb\u901f\u51c6\u786e\u5730\u9884\u6d4b\u5206\u5b50\u6027\u8d28\u81f3\u5173\u91cd\u8981\u3002\u4f20\u7edf\u65b9\u6cd5\u5982\u5b9e\u9a8c\u6d4b\u91cf\u548c\u91cf\u5b50\u5316\u5b66\u6a21\u62df\u867d\u7136\u7cbe\u786e\u4f46\u6210\u672c\u9ad8\u6602\u3002\u8fd1\u5e74\u6765\uff0c\u673a\u5668\u5b66\u4e60\u7279\u522b\u662f\u56fe\u795e\u7ecf\u7f51\u7edc\uff08GNN\uff09\u6210\u4e3a\u5206\u5b50\u6027\u8d28\u9884\u6d4b\u7684\u91cd\u8981\u5de5\u5177\u3002\u7136\u800c\uff0c\u5f53\u6570\u636e\u96c6\u89c4\u6a21\u8f83\u5c0f\u65f6\uff0c\u8bf8\u5982Chemprop\u7b49\u5b66\u4e60\u8868\u793a\u6a21\u578b\uff08Learned Representation Models\uff09\u9762\u4e34\u8fc7\u62df\u5408\u3001\u6cdb\u5316\u5dee\u7684\u95ee\u9898\uff0c\u8868\u73b0\u53cd\u800c\u4e0d\u5982\u4f20\u7edf\u7684Random Forest\u7b49\u57fa\u7ebf\u65b9\u6cd5\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\uff0c\u672c\u6587\u5f15\u5165\u4e86\u4e00\u79cd\u65b0\u9896\u7684\u57fa\u7840\u6a21\u578bCheMeleon\uff0c\u4f7f\u7528\u9884\u8ba1\u7b97\u7684\u5206\u5b50\u63cf\u8ff0\u7b26\u4f5c\u4e3a\u4f4e\u566a\u58f0\u8bad\u7ec3\u76ee\u6807\uff0c\u9884\u8bad\u7ec3\u4e00\u4e2a\u56fe\u795e\u7ecf\u7f51\u7edc\u6a21\u578b\uff0c\u4ee5\u6784\u5efa\u53ef\u8fc1\u79fb\u3001\u9ad8\u8868\u8fbe\u529b\u7684\u5206\u5b50\u8868\u793a\u3002<\/p>\n\n\n\n

\u4e8c\u3001CheMeleon\u6a21\u578b\u8bbe\u8ba1\u4e0e\u9884\u8bad\u7ec3\u7b56\u7565
CheMeleon\u6784\u5efa\u4e8eChemprop\u6846\u67b6\u4e0a\uff0c\u5176\u6838\u5fc3\u4e3aDirected Message-Passing Neural Network\uff08D-MPNN\uff09\uff0c\u642d\u914d\u5168\u8fde\u63a5\u7f51\u7edc\uff08FNN\uff09\u4f5c\u4e3a\u56de\u5f52\u5668\u3002\u5728\u9884\u8bad\u7ec3\u9636\u6bb5\uff0c\u8be5\u6a21\u578b\u4ee5Mordred\u63cf\u8ff0\u7b26\u4e3a\u9884\u6d4b\u76ee\u6807\u8fdb\u884c\u8bad\u7ec3\uff0c\u8fd9\u4e9b\u63cf\u8ff0\u7b26\u662f\u4ecePubChem\u4e2d\u7ea6100\u4e07\u5206\u5b50\u7ed3\u6784\u56fe\u76f4\u63a5\u8ba1\u7b97\u5f97\u51fa\uff0c\u5305\u62ec\u7ed3\u6784\u8ba1\u6570\u3001\u62d3\u6251\u590d\u6742\u6027\u3001\u539f\u5b50\u4f53\u79ef\u7b49\u4fe1\u606f\u3002\u56e0\u4e3a\u8fd9\u4e9b\u63cf\u8ff0\u7b26\u672c\u8eab\u662f\u786e\u5b9a\u6027\u8ba1\u7b97\u800c\u975e\u5b9e\u9a8c\u6d4b\u91cf\u6216QM\u6a21\u62df\uff0c\u56e0\u6b64\u5927\u5927\u51cf\u5c11\u4e86\u7cfb\u7edf\u8bef\u5dee\u4e0e\u566a\u58f0\u5e72\u6270\u3002\u8bad\u7ec3\u8fc7\u7a0b\u4f7f\u7528PyTorch Lightning\u5b9e\u73b0\uff0c\u6a21\u578b\u7ed3\u6784\u4e3a6\u5c42\u9690\u85cf\u5c42D-MPNN\u548c3\u5c42FNN\uff0c\u6bcf\u5c42\u7ef4\u5ea62048\uff0c\u8bad\u7ec3\u76ee\u6807\u4e3a\u6700\u5c0f\u5316\u9884\u6d4b\u4e0e\u771f\u5b9e\u63cf\u8ff0\u7b26\u7684\u5747\u65b9\u8bef\u5dee<\/strong>\u3002<\/p>\n\n\n\n

\u4e09\u3001\u57fa\u51c6\u6d4b\u8bd5\u4e0e\u6027\u80fd\u5206\u6790
\u8bba\u6587\u572858\u4e2a\u4e0d\u540c\u6570\u636e\u96c6\u4e0a\u8bc4\u4f30\u4e86CheMeleon\u7684\u6027\u80fd\uff0c\u5305\u62ecPolaris\u57fa\u51c6\u96c6\u548cMoleculeACE\u6d3b\u6027\u60ac\u5d16\u6311\u6218\u96c6\u3002
\u5728Polaris\u6d4b\u8bd5\u4e2d\uff0cCheMeleon\u572828\u4e2a\u4efb\u52a1\u4e2d\u8d62\u5f9722\u4e2a\uff0c\u80dc\u7387\u8fbe79%\uff0c\u8fdc\u8d85\u5176\u4ed6\u6a21\u578b\uff08\u5982Random Forest 46%\u3001Chemprop 36%\uff09\u3002\u5c24\u5176\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u867d\u7136Chemprop\u4f5c\u4e3a\u57fa\u7840\u67b6\u6784\uff0c\u4f46CheMeleon\u663e\u8457\u8d85\u8d8a\u5176\u8868\u73b0\uff0c\u663e\u793a\u51fa\u63cf\u8ff0\u7b26\u9a71\u52a8\u7684\u9884\u8bad\u7ec3\u7b56\u7565\u6709\u6548\u63d0\u5347\u8868\u793a\u5b66\u4e60\u80fd\u529b\u3002
\u5728MoleculeACE\u6311\u6218\u4e2d\uff0c\u8be5\u6d4b\u8bd5\u4e13\u6ce8\u4e8e\u8bc4\u4f30\u6a21\u578b\u5728\u201cactivity cliffs\u201d\uff08\u5373\u7ed3\u6784\u76f8\u8fd1\u4f46\u6d3b\u6027\u5dee\u5f02\u6781\u5927\u7684\u5206\u5b50\uff09\u4e0a\u7684\u8868\u73b0\u3002\u5c3d\u7ba1\u6574\u4f53\u4e0a\u6240\u6709\u6a21\u578b\u5728\u8bc6\u522bcliffs\u65b9\u9762\u5747\u5b58\u5728\u56f0\u96be\uff0c\u4f46CheMeleon\u4ecd\u4ee597%\u7684\u80dc\u7387\u5c45\u9996\uff0829\/30\uff09\uff0c\u4f18\u4e8eRandom Forest\uff0863%\uff09\u3002\u7136\u800c\uff0c\u51e0\u4e4e\u6240\u6709\u6a21\u578b\uff0c\u5305\u62ecCheMeleon\uff0c\u5728cliff\u4e0enoncliff\u5206\u5b50\u95f4RMSE\u8868\u73b0\u5dee\u5f02\u8f83\u5927\uff0c\u8868\u660e\u5f53\u524d\u9884\u8bad\u7ec3\u65b9\u6cd5\u5c1a\u96be\u6355\u6349\u8fd9\u79cd\u5fae\u5999\u4f46\u5173\u952e\u7684\u7ed3\u6784-\u6027\u8d28\u975e\u7ebf\u6027\u5173\u7cfb\u3002<\/p>\n\n\n\n

\u56db\u3001\u5206\u5b50\u6307\u7eb9\u8868\u793a\u80fd\u529b\u5206\u6790
\u4e3a\u4e86\u8fdb\u4e00\u6b65\u9a8c\u8bc1CheMeleon\u5b66\u4e60\u5230\u7684\u5206\u5b50\u8868\u793a\u7684\u7ed3\u6784\u654f\u611f\u6027\uff0c\u4f5c\u8005\u4f7f\u7528O\u2019Boyle\u548cSayle\u7684\u201cSingle Assay Benchmark\u201d\u5bf9\u5176\u8fdb\u884c\u4e86\u5206\u6790\u3002\u5bf9\u6bd4\u4e86\u4e00\u7cfb\u5217\u4f20\u7edf\u5206\u5b50\u6307\u7eb9\uff08\u5982Morgan\u3001MACCS\u3001RDKit\u7b49\uff09\uff0cCheMeleon\u7684\u8868\u793a\u80fd\u5728t-SNE\u6295\u5f71\u4e2d\u6e05\u6670\u5730\u533a\u5206\u5206\u5b50\u7cfb\u5217\uff0c\u7279\u522b\u662f\u80fd\u8bc6\u522b\u5982\u7532\u6491\u4e8c\u6c27\u57fa\u7684\u79fb\u9664\u5bf9\u5316\u5b66\u7a7a\u95f4\u6295\u5f71\u9020\u6210\u7684\u5206\u88c2\u3002\u8fd9\u663e\u793aCheMeleon\u786e\u5b9e\u6355\u6349\u5230\u4e86\u5316\u5b66\u7ed3\u6784\u4e2d\u7684\u7ec6\u7c92\u5ea6\u5dee\u5f02\uff0c\u4e14\u5176\u4f4e\u7ef4\u5d4c\u5165\u6bd4\u4f20\u7edf\u6307\u7eb9\u66f4\u5177\u5316\u5b66\u4e00\u81f4\u6027\u4e0e\u7ed3\u6784\u654f\u611f\u6027\u3002<\/p>\n\n\n\n

\u4e94\u3001\u65b9\u6cd5\u6bd4\u8f83\u4e0e\u6d88\u878d\u5b9e\u9a8c
\u672c\u6587\u8fd8\u5bf9\u6bd4\u4e86\u591a\u79cd\u6a21\u578b\uff0c\u5305\u62ec\uff1a<\/p>\n\n\n\n

    \n
  1. Chemprop\uff1a\u968f\u673a\u521d\u59cb\u5316\u7684D-MPNN\u3002<\/li>\n\n\n\n
  2. fastprop\uff1a\u57fa\u4e8e\u56fa\u5b9a\u63cf\u8ff0\u7b26\u7684\u524d\u9988\u795e\u7ecf\u7f51\u7edc\u3002<\/li>\n\n\n\n
  3. RF-Morgan\/RF-Mordred\uff1a\u4f20\u7edf\u968f\u673a\u68ee\u6797\u6a21\u578b\uff0c\u4f7f\u7528\u4e0d\u540c\u63cf\u8ff0\u7b26\u3002<\/li>\n\n\n\n
  4. PCA-MLP\uff1a\u5c06\u63cf\u8ff0\u7b26\u964d\u7ef4\u540e\u8f93\u5165MLP\u56de\u5f52\u5668\u3002<\/li>\n\n\n\n
  5. MoLFormer\u3001MolCLR\uff1a\u5206\u522b\u57fa\u4e8eSMILES\u548c\u56fe\u7684\u9884\u8bad\u7ec3\u6a21\u578b\u3002<\/li>\n\n\n\n
  6. minimol\uff1a\u4f4e\u53c2\u6570\u91cf\u56fe\u795e\u7ecf\u7f51\u7edc\u57fa\u7840\u6a21\u578b\u3002
    CheMeleon\u7684\u8868\u73b0\u4e0d\u4ec5\u5728\u7edd\u5bf9\u503c\u4e0a\u9886\u5148\uff0c\u800c\u4e14\u5728\u5404\u79cd\u6a21\u578b\u4e2d\u5c55\u793a\u4e86\u66f4\u4e00\u81f4\u3001\u66f4\u7a33\u5b9a\u7684\u6027\u80fd\uff0c\u8bf4\u660e\u63cf\u8ff0\u7b26\u9a71\u52a8\u9884\u8bad\u7ec3\u7b56\u7565\u5728\u5c0f\u6837\u672c\u548c\u6311\u6218\u6027\u4efb\u52a1\u4e0a\u5177\u6709\u660e\u663e\u4f18\u52bf\u3002<\/li>\n<\/ol>\n\n\n\n

    \u516d\u3001\u7ed3\u8bba\u4e0e\u672a\u6765\u65b9\u5411
    \u4f5c\u8005\u8ba4\u4e3a\u6700\u91cd\u8981\u7684\u53d1\u73b0\u5728\u4e8e\uff1a\u4e0d\u9700\u8981\u6602\u8d35\u7684\u5b9e\u9a8c\u6570\u636e\u6216\u9ad8\u6210\u672c\u7684\u91cf\u5b50\u5316\u5b66\u6a21\u62df\uff0c\u4ec5\u51ed\u53ef\u786e\u5b9a\u6027\u8ba1\u7b97\u7684\u5206\u5b50\u63cf\u8ff0\u7b26\u4e5f\u53ef\u4ee5\u5b9e\u73b0\u9ad8\u6548\u7684\u57fa\u7840\u6a21\u578b\u9884\u8bad\u7ec3\u3002\u8fd9\u79cd\u65b9\u6cd5\u4e0d\u4ec5\u66f4\u6613\u4e8e\u6269\u5c55\uff0c\u4e5f\u907f\u514d\u4e86\u5b9e\u9a8c\u6570\u636e\u4e2d\u7684\u7cfb\u7edf\u6027\u8bef\u5dee\u6216\u5b9e\u9a8c\u5ba4\u95f4\u504f\u5dee\u95ee\u9898\u3002\u672a\u6765\u7684\u7814\u7a76\u53ef\u4ee5\u8fdb\u4e00\u6b65\u63a2\u7d22\u4e0d\u540c\u7684\u63cf\u8ff0\u7b26\u96c6\u5408\uff08\u5982DRAGON\u3001PaDEL\u7b49\uff09\u3001\u4e0d\u540c\u9886\u57df\u7684\u672a\u6807\u8bb0\u6570\u636e\u96c6\uff08\u5982ChEMBL\u3001CoCONUT\uff09\uff0c\u5bfb\u627e\u6700\u6709\u6548\u7684\u7ec4\u5408\u3002\u6b64\u5916\uff0c\u8fd8\u5e94\u7814\u7a76CheMeleon\u5728\u591a\u4efb\u52a1\u5b66\u4e60\u3001\u7ed3\u6784\u751f\u6210\u3001\u836f\u7269\u53d1\u73b0\u7b49\u4efb\u52a1\u4e2d\u7684\u6f5c\u529b\uff0c\u5e76\u4f18\u5316\u5176\u5bf9activity cliffs\u7b49\u5173\u952e\u533a\u57df\u7684\u8bc6\u522b\u80fd\u529b\u3002<\/p>\n\n\n\n

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      \n
    1. \u9884\u8bad\u7ec3\u76ee\u6807\u4e3aMordred\u63cf\u8ff0\u7b26\uff08\u51711613\u4e2a\u7ef4\u5ea6\uff09\uff0c\u6570\u636e\u4ee5Zarr\u683c\u5f0f\u5b58\u50a8\u4ee5\u52a0\u5feb\u8bad\u7ec3\u52a0\u8f7d\u901f\u5ea6\u3002<\/li>\n\n\n\n
    2. \u9664D-MPNN\u7ed3\u6784\u5916\uff0c\u4f5c\u8005\u8fd8\u5c1d\u8bd5\u4e86MLP-PLR\u4f5c\u4e3aAutoencoder\u4ee5\u6a21\u4eff\u5982ChemBERTa\u7684\u9884\u8bad\u7ec3\u65b9\u5f0f\uff1b\u4f7f\u7528PCA-MLP\u5bf9\u63cf\u8ff0\u7b26\u8fdb\u884c\u964d\u7ef4\u5904\u7406\u4ee5\u51cf\u5c11\u8f93\u5165\u7ef4\u5ea6\u3002<\/li>\n\n\n\n
    3. \u6a21\u578b\u8bc4\u4f30\u5747\u5728\u76f8\u540c\u6570\u636e\u5206\u5272\u3001\u968f\u673a\u79cd\u5b50\u8bbe\u5b9a\u4e0b\u8fdb\u884c\uff0c\u907f\u514d\u8d85\u53c2\u6570\u4f18\u5316\u5f15\u8d77\u7684\u8fc7\u62df\u5408\uff0c\u91c7\u7528Tukey HSD\u7edf\u8ba1\u68c0\u9a8c\u8fdb\u884c\u6a21\u578b\u95f4\u5dee\u5f02\u663e\u8457\u6027\u5206\u6790\u3002<\/li>\n<\/ol>\n\n\n\n

      \u516b\u3001\u7ed3\u8bed
      CheMeleon\u5f00\u8f9f\u4e86\u4e00\u4e2a\u65b0\u7684\u8303\u5f0f\uff1a\u901a\u8fc7\u4f7f\u7528\u7ed3\u6784\u6027\u63cf\u8ff0\u7b26\u8fdb\u884c\u9884\u8bad\u7ec3\uff0c\u6253\u9020\u51fa\u8f7b\u91cf\u3001\u7a33\u5b9a\u4e14\u6027\u80fd\u4f18\u5f02\u7684\u57fa\u7840\u6a21\u578b\u3002\u8fd9\u79cd\u65b9\u6cd5\u4e0d\u4ec5\u5728\u5206\u5b50\u6027\u8d28\u9884\u6d4b\u4e2d\u53d6\u5f97\u663e\u8457\u6210\u679c\uff0c\u4e5f\u4e3a\u4f4e\u566a\u58f0\u76d1\u7763\u5b66\u4e60\u63d0\u4f9b\u4e86\u7406\u8bba\u4e0e\u5b9e\u8df5\u652f\u6301\u3002\u672a\u6765\u6709\u671b\u6269\u5c55\u81f3\u5408\u6210\u53ef\u884c\u6027\u9884\u6d4b\u3001\u53cd\u5e94\u9884\u6d4b\u4e43\u81f3\u9006\u5408\u6210\u5206\u6790\u7b49\u66f4\u590d\u6742\u7684\u5316\u5b66AI\u4efb\u52a1\u4e2d\u3002\u4f5c\u8005\u5df2\u5c06\u4ee3\u7801\u5f00\u6e90\u81f3 GitHub\uff0c\u4fbf\u4e8e\u793e\u533a\u590d\u73b0\u4e0e\u62d3\u5c55\u8be5\u65b9\u6cd5\u3002<\/p>\n\n\n\n

      \n\n\n\n

      CheMeleon on GitHub: https:\/\/github.com\/JacksonBurns\/CheMeleon<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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