{"id":5103,"date":"2024-11-16T16:22:16","date_gmt":"2024-11-16T08:22:16","guid":{"rendered":"https:\/\/nullthought.net\/?p=5103"},"modified":"2025-02-21T17:22:58","modified_gmt":"2025-02-21T09:22:58","slug":"evo%ef%bc%9a%e5%9f%ba%e5%9b%a0%e7%bb%84%e5%b0%ba%e5%ba%a6%e4%b8%8a%e7%9a%84%e7%94%9f%e6%88%90%e5%bc%8fai%e7%94%9f%e7%89%a9%e5%9f%ba%e7%a1%80%e6%a8%a1%e5%9e%8b","status":"publish","type":"post","link":"https:\/\/nullthought.net\/?p=5103","title":{"rendered":"Evo\uff1a\u57fa\u56e0\u7ec4\u5c3a\u5ea6\u4e0a\u7684\u751f\u6210\u5f0fAI\u751f\u7269\u57fa\u7840\u6a21\u578b"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong><a href=\"https:\/\/arcinstitute.org\/news\/blog\/evo-science\" target=\"_blank\" rel=\"noreferrer noopener\">Evo<\/a><\/strong>\u662f\u7531Arc\u7814\u7a76\u6240\uff08Arc Institute\uff09\u3001\u65af\u5766\u798f\u5927\u5b66\u548c\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u7684\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u7684\u751f\u6210\u5f0fAI\u751f\u7269\u57fa\u7840\u6a21\u578b\u3002Evo\u7528\u751f\u6210\u5f0fAI\u6765\u7406\u89e3\u548c\u8bbe\u8ba1\u57fa\u56e0\u7ec4\uff0c\u5176\u4e0d\u4ec5\u80fd\u591f\u5728DNA\u5c42\u9762\u8fdb\u884c\u6df1\u5165\u7684\u9884\u6d4b\u548c\u8bbe\u8ba1\uff0c\u8fd8\u53ef\u6269\u5c55\u5230RNA\u548c\u86cb\u767d\u8d28\u5c42\u9762\uff0c\u662f\u4e00\u4e2a\u771f\u6b63\u7684\u751f\u7269\u57fa\u7840\u6a21\u578b\uff0c\u4e3a\u590d\u6742\u7684\u751f\u547d\u7cfb\u7edf\u63d0\u4f9b\u4e86\u7edf\u4e00\u7684\u7406\u89e3\u548c\u64cd\u4f5c\u6846\u67b6\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Evo\u7684\u95ee\u4e16\u6807\u5fd7\u7740\u751f\u6210\u5f0fAI\u5728\u751f\u7269\u5b66\u9886\u57df\u7684\u65b0\u5e94\u7528\u3002\u901a\u8fc7Evo\uff0c\u79d1\u5b66\u5bb6\u4eec\u80fd\u591f\u7406\u89e3\u5e76\u8bbe\u8ba1\u5168\u65b0\u7684\u751f\u7269\u5e8f\u5217\uff0c\u4ece\u800c\u4e3a\u57fa\u56e0\u7ec4\u5b66\u548c\u751f\u7269\u5de5\u7a0b\u5e26\u6765\u5168\u65b0\u7684\u7814\u7a76\u5de5\u5177\u3002\u8fd9\u4e00\u6a21\u578b\u7684\u591a\u6a21\u6001\u3001\u591a\u5c3a\u5ea6\u7279\u6027\uff0c\u4f7f\u5176\u80fd\u591f\u5728\u751f\u7269\u5b66\u5404\u4e2a\u5c42\u6b21\u4e0a\u5b9e\u73b0\u9884\u6d4b\u548c\u8bbe\u8ba1\uff0c\u6781\u5927\u5730\u63a8\u52a8\u4e86\u57fa\u7840\u751f\u7269\u5b66\u7814\u7a76\u548c\u5e94\u7528\u751f\u7269\u6280\u672f\u7684\u53d1\u5c55\u3002\u540c\u65f6\uff0c\u8de8\u5b66\u79d1\u56e2\u961f\u7684\u534f\u4f5c\u4f7f\u5f97\u6a21\u578b\u7684\u5f00\u53d1\u548c\u9a8c\u8bc1\u5f97\u5230\u4e86\u5145\u5206\u7684\u652f\u6301\u548c\u68c0\u9a8c\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/arcinstitute.org\/manuscripts\/Evo\" target=\"_blank\" rel=\"noreferrer noopener\">Evo\u6a21\u578b<\/a>\u7684\u5f00\u53d1\u7531Brian Hie\u3001Patrick Hsu\u7b49\u79d1\u5b66\u5bb6\u9886\u8854\uff0c\u5176\u4e3b\u8981\u76ee\u7684\u662f\u89e3\u51b3\u57fa\u56e0\u7ec4\u4e2d\u5404\u4e2a\u5c42\u6b21\u7684\u590d\u6742\u6027\u2014\u2014\u4ece\u78b1\u57fa\u5230\u57fa\u56e0\u7ec4\uff0c\u4eceRNA\u5230\u86cb\u767d\u8d28\u7684\u8de8\u5c42\u6b21\u5173\u7cfb\u3002DNA\u4f5c\u4e3a\u751f\u547d\u7684\u84dd\u56fe\uff0c\u901a\u8fc7RNA\u548c\u86cb\u767d\u8d28\u7684\u4f5c\u7528\u6267\u884c\u751f\u7269\u529f\u80fd\uff0c\u4f46\u8fd9\u4e9b\u5206\u5b50\u95f4\u590d\u6742\u7684\u76f8\u4e92\u4f5c\u7528\u548c\u65b0\u529f\u80fd\u5e8f\u5217\u7684\u751f\u6210\uff0c\u4e00\u76f4\u662f\u79d1\u5b66\u5bb6\u96be\u4ee5\u653b\u514b\u7684\u96be\u9898\u3002\u4f20\u7edf\u7684\u65b9\u6cd5\u4e3b\u8981\u4f9d\u8d56\u4e8e\u5728\u81ea\u7136\u754c\u4e2d\u5bfb\u627e\u5df2\u6709\u7684\u751f\u7269\u7cfb\u7edf\uff0c\u6bd4\u5982\u5229\u7528\u5df2\u5b58\u5728\u7684CRISPR\u5de5\u5177\uff0c\u800cEvo\u5219\u901a\u8fc7\u5b66\u4e60DNA\u4e2d\u9690\u85cf\u7684\u4fe1\u606f\uff0c\u8fdb\u884c\u8de8\u5c3a\u5ea6\u7684\u9884\u6d4b\u548c\u751f\u6210\uff0c\u8fd9\u5728\u57fa\u56e0\u7ec4\u5c3a\u5ea6\u7684\u5c42\u9762\u4e0a\uff0c\u5f00\u8f9f\u4e86\u5168\u65b0\u7684\u7814\u7a76\u8def\u5f84\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Evo\u7684\u72ec\u7279\u4e4b\u5904\u5728\u4e8e\u5b83\u662f\u4e00\u79cd\u201c\u751f\u7269\u57fa\u7840\u6a21\u578b\u201d\uff08biological foundation model\uff09\uff0c\u7c7b\u4f3c\u4e8e\u6211\u4eec\u5728\u81ea\u7136\u8bed\u8a00\u5904\u7406\u4e2d\u770b\u5230\u7684\u8bed\u8a00\u6a21\u578b\uff0c\u53ea\u4e0d\u8fc7\u5b83\u7684\u8f93\u5165\u662f\u751f\u7269\u5e8f\u5217\u800c\u975e\u6587\u672c\u4fe1\u606f\u3002Evo\u7684\u76ee\u6807\u662f\u89e3\u8bfb\u4ebf\u4e07\u5e74\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u5199\u5165DNA\u7684\u6a21\u5f0f\uff0c\u5e76\u5229\u7528\u8fd9\u4e9b\u6a21\u5f0f\u8bbe\u8ba1\u51fa\u5177\u6709\u751f\u7269\u529f\u80fd\u7684\u5168\u65b0\u5206\u5b50\u5de5\u5177\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Evo\u7684\u5f00\u53d1\u662f\u7531\u4e00\u4e2a\u8de8\u5b66\u79d1\u56e2\u961f\u8fdb\u884c\u7684\uff0c\u5305\u62ec\u8ba1\u7b97\u673a\u79d1\u5b66\u3001\u8ba1\u7b97\u751f\u7269\u5b66\u3001\u5b9e\u9a8c\u751f\u7269\u5b66\u7b49\u591a\u4e2a\u9886\u57df\u7684\u7814\u7a76\u4eba\u5458\u3002\u6a21\u578b\u7684\u6784\u5efa\u91c7\u7528\u4e86\u524d\u6cbf\u7684\u6df1\u5ea6\u5b66\u4e60\u67b6\u6784\uff0c\u5177\u6709\u9ad8\u5ea6\u7684\u53ef\u6269\u5c55\u6027\u548c\u591a\u6a21\u6001\u7279\u6027\u3002Evo\u7684\u8bad\u7ec3\u6570\u636e\u6db5\u76d6\u4e86\u5e7f\u6cdb\u7684DNA\u5e8f\u5217\uff0c\u901a\u8fc7\u8fd9\u4e9b\u6570\u636e\uff0c\u5b83\u80fd\u591f\u4ece\u4f4e\u5c42\u6b21\u7684\u78b1\u57fa\u5bf9\u4fe1\u606f\u4e00\u76f4\u5b66\u4e60\u5230\u66f4\u9ad8\u5c42\u6b21\u7684\u751f\u7269\u5b66\u529f\u80fd\u3002\u6a21\u578b\u7684\u591a\u6a21\u6001\u7279\u6027\u4f7f\u5176\u53ef\u4ee5\u540c\u65f6\u5904\u7406\u5e76\u6574\u5408\u4e0d\u540c\u5c42\u6b21\u7684\u751f\u7269\u4fe1\u606f\uff0c\u4f8b\u5982DNA\u5e8f\u5217\u7684\u7f16\u7801\u4fe1\u606f\u3001RNA\u5206\u5b50\u7684\u8f6c\u5f55\u6a21\u5f0f\u4ee5\u53ca\u86cb\u767d\u8d28\u7684\u529f\u80fd\u7279\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u6a21\u578b\u7684\u8bad\u7ec3\u8fc7\u7a0b\u4e2d\uff0c\u56e2\u961f\u6784\u5efa\u5e76\u6574\u5408\u4e86\u5927\u89c4\u6a21\u7684\u751f\u7269\u5e8f\u5217\u6570\u636e\u96c6\uff0c\u4ee5\u4fdd\u8bc1\u6a21\u578b\u53ef\u4ee5\u5168\u9762\u5730\u7406\u89e3\u548c\u9884\u6d4b\u751f\u7269\u529f\u80fd\u7684\u590d\u6742\u5173\u7cfb\u3002\u6a21\u578b\u7684\u6784\u67b6\u8bbe\u8ba1\u548c\u6269\u5c55\u7531\u65af\u5766\u798f\u751f\u7269\u5de5\u7a0b\u7cfb\u7684\u535a\u58eb\u751fEric Nguyen\u548c\u8ba1\u7b97\u673a\u79d1\u5b66\u7cfb\u7684\u535a\u58eb\u751fMichael Poli\u8d1f\u8d23\uff0c\u800cHsu\u5b9e\u9a8c\u5ba4\u7684Arc\u7814\u7a76\u6240\u9ad8\u7ea7\u79d1\u5b66\u5bb6Matthew Durrant\u5219\u9886\u5bfc\u4e86\u8ba1\u7b97\u751f\u7269\u5b66\u7684\u5b50\u56e2\u961f\uff0c\u4e13\u6ce8\u4e8e\u751f\u7269\u5e8f\u5217\u7684\u6570\u636e\u5e93\u7ba1\u7406\u4e0e\u4e0b\u6e38\u4efb\u52a1\u7684\u6a21\u578b\u8bc4\u4f30\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b9e\u9a8c\u751f\u7269\u5b66\u9a8c\u8bc1\u662fEvo\u5f00\u53d1\u4e2d\u7684\u91cd\u8981\u73af\u8282\uff0c\u7531\u65af\u5766\u798f\u7684\u535a\u58eb\u751fBrian Kang\u3001David Li\u4ee5\u53caHsu\u5b9e\u9a8c\u5ba4\u7684\u9ad8\u7ea7\u79d1\u5b66\u5bb6Dhruva Katrekar\u9886\u5bfc\u3002\u4e3a\u4e86\u9a8c\u8bc1Evo\u7684\u751f\u6210\u80fd\u529b\uff0c\u7814\u7a76\u4eba\u5458\u9996\u5148\u5c1d\u8bd5\u4f7f\u7528\u5b83\u6765\u8bbe\u8ba1\u65b0\u7684CRISPR\u7cfb\u7edf\uff0c\u79f0\u4e3aEvoCas9-1\u3002\u8fd9\u4e00\u7cfb\u7edf\u4e0e\u5e38\u89c1\u7684CRISPR-Cas9\u7cfb\u7edf\u76f8\u6bd4\uff0c\u5176\u5e8f\u5217\u76f8\u4f3c\u5ea6\u53ea\u6709\u5927\u7ea673%\uff0c\u5374\u5728\u5b9e\u9a8c\u4e2d\u8868\u73b0\u51fa\u4e86\u76f8\u4f3c\u7684\u57fa\u56e0\u7f16\u8f91\u6d3b\u6027\u3002\u4f20\u7edf\u4e0a\uff0c\u8bbe\u8ba1CRISPR\u7cfb\u7edf\u9700\u8981\u5728\u81ea\u7136\u754c\u4e2d\u5bfb\u627e\u5408\u9002\u7684\u86cb\u767d\u8d28\u548cRNA\u914d\u5bf9\uff0c\u800cEvo\u901a\u8fc7\u540c\u65f6\u8bbe\u8ba1\u86cb\u767d\u8d28\u548cRNA\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u529f\u80fd\u6027\u7684\u65b0CRISPR\u5de5\u5177\u7684\u751f\u6210\u3002\u8fd9\u79cd\u80fd\u529b\u5c55\u793a\u4e86Evo\u5728\u5206\u5b50\u751f\u7269\u5b66\u5de5\u5177\u5f00\u53d1\u4e2d\u7684\u5de8\u5927\u6f5c\u529b\uff0c\u4e3a\u672a\u6765\u7684\u57fa\u56e0\u7f16\u8f91\u7814\u7a76\u63d0\u4f9b\u4e86\u66f4\u591a\u53ef\u80fd\u6027\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e3a\u4e86\u8fdb\u4e00\u6b65\u9a8c\u8bc1Evo\u7684\u80fd\u529b\uff0c\u7814\u7a76\u4eba\u5458\u8fd8\u8981\u6c42\u5b83\u8bbe\u8ba1\u4e86\u4e00\u4e9b\u57fa\u56e0\u7ec4\u4e2d\u7684\u79fb\u52a8\u9057\u4f20\u5143\u4ef6\uff0c\u5982IS200\/IS605\u8f6c\u5ea7\u5b50\u3002\u8fd9\u4e9b\u8f6c\u5ea7\u5b50\u901a\u8fc7\u590d\u6742\u7684\u201c\u5265\u79bb-\u7c98\u8d34\u201d\u673a\u5236\u5728\u57fa\u56e0\u7ec4\u4e2d\u8fdb\u884c\u79fb\u52a8\uff0c\u9700\u8981\u591a\u4e2a\u6210\u5206\u4e4b\u95f4\u7684\u7cbe\u5bc6\u534f\u8c03\uff0c\u5305\u62ec\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u914d\u5bf9\u3001\u7279\u5b9aDNA\u7ed3\u6784\u7684\u6298\u53e0\uff08\u5982\u53d1\u5939\u7ed3\u6784\uff09\uff0c\u4ee5\u53caRNA\u5206\u5b50\u7684\u5f15\u5bfc\u7b49\u3002Evo\u4e0d\u4ec5\u8bbe\u8ba1\u51fa\u4e86\u65b0\u578b\u7684\u8f6c\u5ea7\u5b50\u5143\u4ef6\uff0c\u8fd9\u4e9b\u5143\u4ef6\u8fd8\u6210\u529f\u5b8c\u6210\u4e86DNA\u7684\u201c\u526a\u5207-\u7c98\u8d34\u201d\u529f\u80fd\uff0c\u8bc1\u660e\u4e86\u5176\u5728\u590d\u6742\u57fa\u56e0\u8bbe\u8ba1\u65b9\u9762\u7684\u6f5c\u529b\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u6a21\u578b\u5f00\u53d1\u7684\u8fc7\u7a0b\u4e2d\uff0c\u7814\u7a76\u56e2\u961f\u540c\u6837\u91cd\u89c6\u4f26\u7406\u4e0e\u5b89\u5168\u95ee\u9898\u3002\u65af\u5766\u798f\u6559\u6388Tina Hernandez-Boussard\u3001\u535a\u58eb\u540e\u5b66\u8005Madalena Ng\u4ee5\u53ca\u535a\u58eb\u751fAshley Lewis\u53c2\u4e0e\u4e86\u5173\u4e8eEvo\u7684\u4f26\u7406\u548c\u5b89\u5168\u6027\u8c03\u67e5\uff0c\u660e\u786e\u4e86\u8fd9\u4e00\u65b0\u6280\u672f\u5728\u5f00\u53d1\u548c\u90e8\u7f72\u4e2d\u7684\u6f5c\u5728\u98ce\u9669\uff0c\u5e76\u5236\u5b9a\u4e86\u76f8\u5e94\u7684\u9884\u9632\u63aa\u65bd\u3002\u968f\u7740\u751f\u7269\u57fa\u7840\u6a21\u578b\u7684\u4e0d\u65ad\u53d1\u5c55\uff0c\u5982\u4f55\u786e\u4fdd\u8fd9\u4e9b\u6a21\u578b\u4e0d\u4f1a\u88ab\u6ee5\u7528\u3001\u5982\u4f55\u89c4\u8303\u5176\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u7684\u5e94\u7528\uff0c\u5c06\u662f\u672a\u6765\u5fc5\u987b\u8981\u89e3\u51b3\u7684\u91cd\u8981\u95ee\u9898\u3002\u56e2\u961f\u7684\u8fd9\u79cd\u524d\u77bb\u6027\u8003\u91cf\uff0c\u53cd\u6620\u4e86\u79d1\u5b66\u5bb6\u4eec\u5bf9\u65b0\u6280\u672f\u5728\u751f\u7269\u5b66\u7814\u7a76\u4e2d\u7684\u53cc\u5203\u5251\u7279\u6027\u7684\u6df1\u523b\u7406\u89e3\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Evo\u7684\u7814\u53d1\u53ea\u662f\u751f\u7269\u5b66\u57fa\u7840\u6a21\u578b\u7814\u7a76\u7684\u8d77\u6b65\uff0c\u56e2\u961f\u7684\u4e0b\u4e00\u4e2a\u76ee\u6807\u662f\u6269\u5c55Evo\u7684\u80fd\u529b\uff0c\u4f7f\u5176\u80fd\u591f\u5e94\u7528\u5230\u66f4\u590d\u6742\u7684\u751f\u7269\u4f53\u548c\u66f4\u5927\u89c4\u6a21\u7684\u751f\u7269\u7ec4\u7ec7\u4e0a\u3002\u4f8b\u5982\uff0c<strong>Evo\u73b0\u5728\u5df2\u7ecf\u80fd\u591f\u751f\u6210\u957f\u5ea6\u8d85\u8fc7100\u4e07\u78b1\u57fa\u7684DNA\u5e8f\u5217<\/strong>\uff0c\u76f8\u5f53\u4e8e\u8bb8\u591a\u7b80\u5355\u751f\u7269\u4f53\u7684\u57fa\u56e0\u7ec4\u89c4\u6a21\u3002\u7814\u7a76\u56e2\u961f\u8ba1\u5212\u5c06Evo\u7684\u5e94\u7528\u6269\u5c55\u5230\u591a\u7ec6\u80de\u751f\u7269\u4f53\uff0c\u63a2\u7d22\u8fd9\u4e9b\u751f\u547d\u5f62\u5f0f\u5982\u4f55\u901a\u8fc7\u6f14\u5316\u5f62\u6210\u7684\u590d\u6742\u7cfb\u7edf\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u76f8\u5173\u9605\u8bfb\uff1a<strong><a href=\"https:\/\/nullthought.net\/?p=5678\" target=\"_blank\" rel=\"noreferrer noopener\">Evo 2\uff1a\u6db5\u76d6\u6240\u6709\u751f\u547d\u9886\u57df\u57fa\u56e0\u7ec4\u6570\u636e\u96c6\u7684\u751f\u7269\u5b66\u57fa\u7840\u6a21\u578b<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Evo\u662f\u7531Arc\u7814\u7a76\u6240\uff08Arc Institute\uff09\u3001\u65af\u5766\u798f\u5927\u5b66\u548c\u52a0\u5dde\u5927\u5b66\u4f2f\u514b\u5229\u5206\u6821\u7684\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u7684\u751f\u6210\u5f0fAI [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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