{"id":4934,"date":"2024-10-23T11:12:58","date_gmt":"2024-10-23T03:12:58","guid":{"rendered":"https:\/\/nullthought.net\/?p=4934"},"modified":"2025-03-20T14:05:33","modified_gmt":"2025-03-20T06:05:33","slug":"%e6%b7%b1%e5%ba%a6%e6%8e%a2%e7%a9%b6deepvariant%e6%a8%a1%e5%9e%8b%ef%bc%88%e5%9f%ba%e5%9b%a0%e5%8f%98%e5%bc%82%e6%a3%80%e6%b5%8b%e6%a8%a1%e5%9e%8b%ef%bc%89%e5%86%85%e9%83%a8%e7%9a%84%e7%89%b9%e5%be%81","status":"publish","type":"post","link":"https:\/\/nullthought.net\/?p=4934","title":{"rendered":"\u6df1\u5ea6\u63a2\u7a76DeepVariant\u6a21\u578b\uff08\u57fa\u56e0\u53d8\u5f02\u68c0\u6d4b\u6a21\u578b\uff09\u5185\u90e8\u7684\u7279\u5f81\u5d4c\u5165\u548c\u9ad8\u7ef4\u7279\u5f81\uff0c\u63ed\u793a\u5176\u5185\u5728\u5de5\u4f5c\u673a\u5236"},"content":{"rendered":"\n<p><strong><a href=\"https:\/\/github.com\/google\/deepvariant\" target=\"_blank\" rel=\"noreferrer noopener\">DeepVariant<\/a><\/strong>\u662f\u7531Google\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u7684\u4e00\u79cd\u57fa\u56e0\u53d8\u5f02\u68c0\u6d4b\u5de5\u5177\uff0c\u4e3b\u8981\u7528\u4e8e\u68c0\u6d4b\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u4e2d\u7684\u5c0f\u53d8\u5f02\u3002\u8fd9\u79cd\u53d8\u5f02\u53ef\u80fd\u662f\u5355\u4e2a\u78b1\u57fa\u7684\u66ff\u6362\uff08\u5982A \u2192 T\uff09\u3001\u77ed\u7247\u6bb5\u7684\u63d2\u5165\u6216\u5220\u9664\uff0c\u8fd9\u4e9b\u90fd\u53ef\u80fd\u5f71\u54cd\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u6216\u57fa\u56e0\u7684\u8868\u8fbe\u3002\u8fd9\u4e9b\u53d8\u5f02\u7684\u51c6\u786e\u8bc6\u522b\u5728\u7f55\u89c1\u75be\u75c5\u7684\u8bca\u65ad\u3001\u764c\u75c7\u7814\u7a76\u4ee5\u53ca\u9057\u4f20\u75c5\u7684\u7814\u7a76\u4e2d\u5177\u6709\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002<\/p>\n\n\n\n<p>DeepVariant\u6700\u521d\u662f\u901a\u8fc7\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u6765\u6a21\u4eff\u4eba\u7c7b\u4e13\u5bb6\u5bf9\u57fa\u56e0\u53d8\u5f02\u7684\u5206\u6790\u8fc7\u7a0b\uff0c\u7ed3\u5408\u4e86\u673a\u5668\u5b66\u4e60\u4e0e\u751f\u7269\u4fe1\u606f\u5b66\u7684\u6280\u672f\uff0c\u65e8\u5728\u81ea\u52a8\u5316\u57fa\u56e0\u7ec4\u53d8\u5f02\u7684\u68c0\u6d4b\u5e76\u63d0\u9ad8\u51c6\u786e\u7387\u3002\u5176\u8bad\u7ec3\u6570\u636e\u6765\u81ea\u4e8e\u56fd\u5bb6\u6807\u51c6\u4e0e\u6280\u672f\u7814\u7a76\u9662\uff08NIST\uff09\u7684\u516d\u4e2a\u7ec6\u80de\u7cfb\uff0c\u8fd9\u4e9b\u7ec6\u80de\u7cfb\u7ecf\u8fc7\u591a\u79cd\u6d4b\u5e8f\u6280\u672f\u548c\u624b\u52a8\u5ba1\u67e5\uff0c\u56e0\u6b64\u57fa\u56e0\u53d8\u5f02\u7684\u4fe1\u606f\u662f\u76f8\u5bf9\u53ef\u4fe1\u7684\u3002DeepVariant\u901a\u8fc7\u5c06\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u4f5c\u4e3a\u8f93\u5165\uff0c\u8f93\u51fa\u53ef\u80fd\u7684\u53d8\u5f02\u6807\u7b7e\uff0c\u7c7b\u4f3c\u4e8e\u8ba1\u7b97\u673a\u89c6\u89c9\u6a21\u578b\u5bf9\u56fe\u50cf\u5206\u7c7b\u7684\u8fc7\u7a0b\u3002<\/p>\n\n\n\n<p>\u8fd1\u65e5\uff0cGoogle\u7814\u7a76\u56e2\u961f\u53d1\u8868\u6587\u7ae0<strong><a href=\"https:\/\/research.google\/blog\/learning-deepvariants-hidden-powers\/\" target=\"_blank\" rel=\"noreferrer noopener\">Learning DeepVariant&#8217;s hidden powers<\/a><\/strong>\uff0c\u9610\u8ff0\u9488\u5bf9DeepVariant\u7684\u76f8\u5173\u7814\u7a76\u6210\u679c\uff0c\u63ed\u793aDeepVariant\u6a21\u578b\u7684\u5185\u5728\u5de5\u4f5c\u673a\u5236\uff0c\u4ee5\u4e86\u89e3\u5b83\u662f\u5982\u4f55\u5728\u57fa\u56e0\u7ec4\u53d8\u5f02\u68c0\u6d4b\u4e2d\u8d85\u8fc7\u5176\u4ed6\u6700\u5148\u8fdb\u5de5\u5177\u7684\u6027\u80fd\u7684\u3002\u7279\u522b\u662f\uff0c\u7814\u7a76\u56e2\u961f\u5e0c\u671b\u901a\u8fc7\u6df1\u5ea6\u63a2\u7a76DeepVariant\u6a21\u578b\u5185\u90e8\u7684\u7279\u5f81\u5d4c\u5165\uff0c\u4e86\u89e3\u5176\u5728\u4e0d\u540c\u5c42\u6b21\u4e0a\u6355\u6349\u7684\u9ad8\u7ef4\u7279\u5f81\u3002\u8fd9\u4e0d\u4ec5\u6709\u52a9\u4e8e\u7406\u89e3\u6a21\u578b\u7684\u51b3\u7b56\u8fc7\u7a0b\uff0c\u4e5f\u53ef\u4ee5\u5e2e\u52a9\u6539\u8fdb\u6a21\u578b\u7684\u6027\u80fd\uff0c\u63d0\u4f9b\u66f4\u591a\u7684\u89e3\u91ca\u6027\uff0c\u4ee5\u66f4\u597d\u5730\u7406\u89e3\u4e3a\u4f55\u67d0\u4e9b\u53d8\u5f02\u88ab\u6210\u529f\u68c0\u6d4b\u5230\uff0c\u800c\u53e6\u4e00\u4e9b\u5374\u6ca1\u6709\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"278\" src=\"https:\/\/nullthought.net\/wp-content\/uploads\/2024\/10\/image-24-1024x278.png\" alt=\"\" class=\"wp-image-4935\" srcset=\"https:\/\/nullthought.net\/wp-content\/uploads\/2024\/10\/image-24-1024x278.png 1024w, https:\/\/nullthought.net\/wp-content\/uploads\/2024\/10\/image-24-300x82.png 300w, https:\/\/nullthought.net\/wp-content\/uploads\/2024\/10\/image-24-768x209.png 768w, https:\/\/nullthought.net\/wp-content\/uploads\/2024\/10\/image-24-1536x418.png 1536w, https:\/\/nullthought.net\/wp-content\/uploads\/2024\/10\/image-24.png 1710w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><strong><a href=\"https:\/\/research.google\/blog\/learning-deepvariants-hidden-powers\/\" target=\"_blank\" rel=\"noreferrer noopener\">Learning DeepVariant&#8217;s hidden powers<\/a><\/strong><\/figcaption><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">\u4e00\u3001<strong>\u65b9\u6cd5\u548c\u5206\u6790\u6b65\u9aa4<\/strong><\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">1. <strong>\u7279\u5f81\u5d4c\u5165\u7684\u53ef\u89c6\u5316<\/strong><\/h5>\n\n\n\n<p>\u4e3a\u4e86\u6df1\u5165\u7406\u89e3DeepVariant\u5bf9\u8f93\u5165\u6570\u636e\u7684\u5b66\u4e60\u8fc7\u7a0b\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u4e86\u4e00\u7cfb\u5217\u7684\u53ef\u89c6\u5316\u548c\u805a\u7c7b\u65b9\u6cd5\u3002\u8fd9\u4e9b\u65b9\u6cd5\u5305\u62ec\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>UMAP\uff08Uniform Manifold Approximation and Projection\uff09<\/strong>\uff1a\u8fd9\u662f\u7528\u4e8e\u964d\u7ef4\u7684\u4e00\u79cd\u975e\u7ebf\u6027\u6280\u672f\uff0c\u7528\u4e8e\u5c06\u9ad8\u7ef4\u7279\u5f81\u6570\u636e\u5d4c\u5165\u5230\u4e8c\u7ef4\u6216\u4e09\u7ef4\u7a7a\u95f4\u4e2d\uff0c\u4fbf\u4e8e\u53ef\u89c6\u5316\u3002\u7814\u7a76\u4eba\u5458\u5c06UMAP\u5e94\u7528\u4e8eDeepVariant\u6a21\u578b\u7684\u4e2d\u95f4\u5c42\uff08mixed5 max-pooling\u5c42\uff09\u7684\u5d4c\u5165\uff0c\u4ee5\u89c2\u5bdf\u6a21\u578b\u5bf9\u8f93\u5165\u57fa\u56e0\u5e8f\u5217\u7684\u4e0d\u540c\u7279\u5f81\u5982\u4f55\u8868\u73b0\u3002<\/li>\n\n\n\n<li><strong>\u4e0d\u540c\u989c\u8272\u8868\u793a\u7684\u5df2\u77e5\u5e8f\u5217\u5c5e\u6027<\/strong>\uff1a\u4f8b\u5982\uff0c\u6d4b\u5e8f\u8d28\u91cf\u4f4e\u7684\u8bfb\u6570\u3001\u96be\u4ee5\u6620\u5c04\u7684\u57fa\u56e0\u7ec4\u533a\u57df\u7b49\u3002\u901a\u8fc7\u8fd9\u4e9b\u989c\u8272\u6807\u8bb0\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u66f4\u76f4\u89c2\u5730\u770b\u5230\u8fd9\u4e9b\u5c5e\u6027\u5728\u9ad8\u7ef4\u7a7a\u95f4\u4e2d\u7684\u5206\u5e03\uff0c\u4ee5\u53ca\u5b83\u4eec\u5728\u6a21\u578b\u5904\u7406\u8fc7\u7a0b\u4e2d\u7684\u8868\u73b0\u3002<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">2. <strong>\u7279\u5f81\u5d4c\u5165\u7684\u805a\u7c7b<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>k-means\u805a\u7c7b<\/strong>\uff1a\u4e3a\u4e86\u8fdb\u4e00\u6b65\u7406\u89e3\u6a21\u578b\u7684\u5185\u90e8\u7279\u5f81\u5206\u5e03\uff0c\u7814\u7a76\u4eba\u5458\u9996\u5148\u4f7f\u7528\u7b80\u5355\u7684k-means\u805a\u7c7b\u65b9\u6cd5\u3002k-means\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u65e0\u76d1\u7763\u805a\u7c7b\u7b97\u6cd5\uff0c\u901a\u8fc7\u6570\u636e\u70b9\u5728\u7279\u5f81\u7a7a\u95f4\u4e2d\u7684\u8ddd\u79bb\u8fdb\u884c\u5206\u7c7b\uff0c\u4e0d\u9700\u8981\u6807\u7b7e\u4fe1\u606f\u3002\u521d\u6b65\u7684\u805a\u7c7b\u53d1\u73b0\u4e86\u4e00\u4e9b\u81ea\u7136\u5f62\u6210\u7684\u7c07\uff0c\u8fd9\u4e9b\u7c07\u5728\u4e0d\u540c\u6a21\u578b\u5c42\u4e2d\u4f53\u73b0\u4e86\u5bf9\u8f93\u5165DNA\u8bfb\u6570\u4e0d\u540c\u4fe1\u606f\u7684\u4fdd\u7559\u7a0b\u5ea6\u3002<\/li>\n\n\n\n<li><strong>\u5c42\u6b21\u805a\u7c7b\uff08Hierarchical Clustering\uff09<\/strong>\uff1a\u4e3a\u4e86\u66f4\u7cbe\u7ec6\u5730\u63a7\u5236\u805a\u7c7b\u7684\u6570\u91cf\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u5bf9\u521d\u59cbk-means\u805a\u7c7b\u7684\u7c07\u8fdb\u884c\u5206\u5272\u3002\u9996\u5148\u8fdb\u884c3\u4e2a\u7c07\u7684\u805a\u7c7b\uff0c\u7136\u540e\u5bf9\u6bcf\u4e2a\u7c07\u518d\u6b21\u5e94\u7528k-means\u805a\u7c7b\uff0c\u7ed3\u679c\u8868\u660e\u4e00\u4e9b\u7c07\u4e0e\u57fa\u56e0\u7ec4\u4e2d\u96be\u4ee5\u6620\u5c04\u7684\u90e8\u5206\u9ad8\u5ea6\u76f8\u5173\uff0c\u5c24\u5176\u662f\u5177\u6709\u76f8\u4f3c\u4f46\u7ec6\u5fae\u5dee\u5f02\u7684\u6d4b\u5e8f\u6df1\u5ea6\u7684\u533a\u57df\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u4e8c\u3001<strong>\u53d1\u73b0\u7684\u751f\u7269\u5b66\u76f8\u5173\u6027<\/strong><\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">1. <strong>LINEs\uff08\u957f\u6563\u5728\u6838\u5143\u7d20\uff09<\/strong><\/h5>\n\n\n\n<p>\u5728\u8fdb\u884c\u8fdb\u4e00\u6b65\u5206\u6790\u65f6\uff0c\u7814\u7a76\u4eba\u5458\u5173\u6ce8\u5230\u67d0\u4e9b\u7c07\u4e0e\u57fa\u56e0\u7ec4\u4e2d\u91cd\u590d\u7684\u533a\u57df\uff08\u4f8b\u5982LINEs\uff09\u9ad8\u5ea6\u76f8\u5173\u3002LINEs\u662f\u4e00\u7c7b\u957f\u8fbe6000\u4e2a\u78b1\u57fa\u5bf9\u7684DNA\u5e8f\u5217\uff0c\u5177\u6709\u5728\u57fa\u56e0\u7ec4\u4e2d\u590d\u5236\u79fb\u52a8\u7684\u80fd\u529b\u3002\u8fd9\u79cd\u590d\u5236\u548c\u79fb\u52a8\u53ef\u4ee5\u6539\u53d8\u57fa\u56e0\u7ec4\u4e2d\u54ea\u4e9b\u90e8\u5206\u88ab\u7528\u4e8e\u86cb\u767d\u8d28\u5408\u6210\uff0c\u53ef\u80fd\u5bf9\u8fdb\u5316\u548c\u5065\u5eb7\u4ea7\u751f\u91cd\u8981\u5f71\u54cd\u3002<\/p>\n\n\n\n<p>\u901a\u8fc7\u5f15\u5165UCSC\u57fa\u56e0\u7ec4\u6570\u636e\u5e93\u4e2d\u7684\u5df2\u77e5LINE\u6807\u6ce8\u6570\u636e\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u67d0\u4e9b\u805a\u7c7b\u7c07\u4e2d\u5305\u542b\u4e86\u5927\u91cf\u7684LINE\u5e8f\u5217\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4e09\u4e2a\u805a\u7c7b\u7c07\uff08\u5206\u522b\u6807\u8bb0\u4e3a2 &#8211; \u6d45\u7eff\u8272\u30013 &#8211; \u7eff\u8272\u30014 &#8211; \u7ea2\u8272\uff09\u4e0e\u57fa\u56e0\u7ec4\u4e2d\u96be\u4ee5\u6620\u5c04\u7684\u533a\u57df\u76f8\u5173\u3002<\/li>\n\n\n\n<li>\u8fdb\u4e00\u6b65\u5206\u6790\u53d1\u73b0\uff0c\u8fd9\u4e09\u4e2a\u7c07\u4e2dLINEs\u7684\u6bd4\u4f8b\u5206\u522b\u4e3a83.9%\u300170.3%\u548c43.9%\uff0c\u8868\u660e\u8fd9\u4e9b\u7c07\u6355\u6349\u5230\u4e86LINEs\u7684\u7279\u5f81\uff0c\u800cDeepVariant\u5e76\u672a\u663e\u5f0f\u63a5\u53d7\u5173\u4e8eLINE\u7684\u8bad\u7ec3\u3002<\/li>\n<\/ul>\n\n\n\n<p>\u8fd9\u79cd\u7ed3\u679c\u8868\u660e\uff0cDeepVariant\u6a21\u578b\u4f3c\u4e4e\u9690\u5f0f\u5730\u5b66\u4e60\u5230\u4e86\u4e0e\u5927\u578b\u57fa\u56e0\u7ec4\u91cd\u6392\u76f8\u5173\u7684\u77e5\u8bc6\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u5176\u5728\u5c0f\u53d8\u5f02\u68c0\u6d4b\u4efb\u52a1\u4e2d\u7684\u8868\u73b0\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">2. <strong>\u5d4c\u5408\u53d8\u5f02<\/strong><\/h5>\n\n\n\n<p>\u5d4c\u5408\u53d8\u5f02\u662f\u6307\u5728\u80da\u80ce\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u7a81\u53d8\uff0c\u8fd9\u4e9b\u7a81\u53d8\u4e0d\u662f\u6765\u81ea\u7236\u6bcd\u9057\u4f20\uff0c\u800c\u662f\u5728\u4e2a\u4f53\u751f\u957f\u8fc7\u7a0b\u4e2d\u5f62\u6210\u7684\u3002\u7814\u7a76\u56e2\u961f\u540c\u6837\u4f7f\u7528UMAP\u8fdb\u884c\u6570\u636e\u53ef\u89c6\u5316\uff0c\u5e76\u901a\u8fc7k-means\u805a\u7c7b\u8bc6\u522b\u4e86\u516d\u4e2a\u53ef\u80fd\u5177\u6709\u5d4c\u5408\u53d8\u5f02\u7279\u5f81\u7684\u6837\u672c\u3002\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e9b\u7ed3\u679c\uff0c\u7814\u7a76\u4eba\u5458\u5f15\u5165\u4e86NIST\u7684\u5df2\u77e5\u5d4c\u5408\u53d8\u5f02\u6570\u636e\u96c6\uff0c\u7ed3\u679c\u53d1\u73b0\u8fd9\u4e9b\u6837\u672c\u5168\u90e8\u843d\u5728\u540c\u4e00\u4e2a\u805a\u7c7b\u7c07\u4e2d\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86DeepVariant\u6a21\u578b\u5728\u68c0\u6d4b\u5d4c\u5408\u53d8\u5f02\u65b9\u9762\u7684\u80fd\u529b\u3002<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u4e09\u3001<strong>\u591a\u5c42\u7279\u5f81\u7684\u7ec4\u5408\u5206\u6790<\/strong><\/h4>\n\n\n\n<p>\u4e3a\u4e86\u8fdb\u4e00\u6b65\u4e86\u89e3\u6a21\u578b\u4e0d\u540c\u5c42\u6b21\u4e0a\u7684\u7279\u5f81\u5b66\u4e60\uff0c\u7814\u7a76\u4eba\u5458\u4eceDeepVariant\u7684\u591a\u4e2a\u5c42\u6b21\u63d0\u53d6\u4e86\u7279\u5f81\u5d4c\u5165\uff0c\u5e76\u5bf9\u6bcf\u4e00\u5c42\u7684\u5d4c\u5165\u5206\u522b\u8fdb\u884cPCA\u964d\u7ef4\uff0c\u7136\u540e\u5c06\u516d\u4e2a\u5c42\u6b21\u7684\u7279\u5f81\u62fc\u63a5\uff0c\u518d\u6b21\u5e94\u7528PCA\u964d\u7ef4\u3002\u8fd9\u79cd\u4e24\u6b21\u964d\u7ef4\u7684\u8fc7\u7a0b\u53ef\u4ee5\u51cf\u5c11\u566a\u58f0\uff0c\u540c\u65f6\u4fdd\u7559\u4e0d\u540c\u5c42\u6b21\u7279\u5f81\u4e4b\u95f4\u7684\u76f8\u5173\u6027\u3002<\/p>\n\n\n\n<p>\u805a\u7c7b\u5206\u6790\u8868\u660e\uff1a<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5d4c\u5408\u6837\u672c\u88ab\u8fdb\u4e00\u6b65\u9694\u79bb\u5230\u4e00\u4e2a\u5305\u542b41\u4e2a\u6837\u672c\u7684\u5c0f\u7c07\u4e2d\uff0842\u4e2a\u6837\u672c\u4e2d\u768441\u4e2a\uff09\u3002<\/li>\n\n\n\n<li>\u8fd9\u79cd\u5c42\u6b21\u5316\u7684\u7279\u5f81\u7ec4\u5408\u4f7f\u5f97\u6a21\u578b\u53ef\u4ee5\u5728\u66f4\u5927\u8303\u56f4\u5185\u7efc\u5408\u4f4e\u5c42\u548c\u9ad8\u5c42\u7684\u7279\u5f81\uff0c\u4ece\u800c\u66f4\u7cbe\u786e\u5730\u5bf9\u5d4c\u5408\u53d8\u5f02\u8fdb\u884c\u5206\u7c7b\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u56db\u3001<strong>\u8ba8\u8bba\u4e0e\u7ed3\u8bba<\/strong><\/h4>\n\n\n\n<p>\u7814\u7a76\u8868\u660e\uff0cDeepVariant\u4e0d\u4ec5\u80fd\u591f\u6210\u529f\u5730\u68c0\u6d4b\u5c0f\u53d8\u5f02\uff0c\u8fd8\u5177\u5907\u4e00\u5b9a\u7a0b\u5ea6\u7684\u68c0\u6d4b\u7ed3\u6784\u53d8\u5f02\uff08\u5982LINEs\u548c\u5d4c\u5408\u53d8\u5f02\uff09\u7684\u80fd\u529b\uff0c\u8fd9\u4e9b\u7279\u6027\u5e76\u672a\u5728\u6a21\u578b\u8bad\u7ec3\u8fc7\u7a0b\u4e2d\u88ab\u663e\u5f0f\u6807\u6ce8\u6216\u6559\u5bfc\u3002\u5c24\u5176\u662f\uff0cDeepVariant\u6bcf\u6b21\u53ea\u5904\u7406\u957f\u5ea6\u4e3a221\u4e2a\u78b1\u57fa\u5bf9\u7684\u8f93\u5165\uff0c\u4f46\u5b83\u7684\u5185\u90e8\u7279\u5f81\u5d4c\u5165\u8868\u73b0\u51fa\u5bf9\u957f\u5ea6\u8fdc\u8d85\u8fc7\u5176\u8f93\u5165\u7684\u53d8\u5f02\uff08\u59826000\u4e2a\u78b1\u57fa\u5bf9\u7684LINEs\uff09\u7684\u53cd\u5e94\uff0c\u8fd9\u8868\u660e\u5b83\u5728\u5904\u7406\u53d8\u5f02\u65f6\u53ef\u80fd\u91c7\u7528\u4e86\u4e00\u4e9b\u66f4\u9ad8\u7ea7\u7684\u6982\u5ff5\u3002<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">1. <strong>\u6a21\u578b\u7684\u542f\u793a<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>\u4ea4\u53c9\u9886\u57df\u77e5\u8bc6\u7684\u5e94\u7528<\/strong>\uff1aDeepVariant\u80fd\u591f\u5229\u7528\u4ece\u66f4\u5927\u57fa\u56e0\u7ec4\u7ed3\u6784\u5206\u6790\u4e2d\u5b66\u5230\u7684\u6982\u5ff5\u6765\u63d0\u9ad8\u5bf9\u5c0f\u53d8\u5f02\u7684\u8bc6\u522b\u80fd\u529b\uff0c\u8fd9\u8868\u660e\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\u80fd\u591f\u9690\u5f0f\u5730\u8de8\u9886\u57df\u5b66\u4e60\uff0c\u5e76\u5c06\u8fd9\u79cd\u5b66\u4e60\u7528\u4e8e\u539f\u59cb\u4efb\u52a1\u7684\u6027\u80fd\u6539\u8fdb\u3002<\/li>\n\n\n\n<li><strong>\u751f\u7269\u5b66\u7279\u6027\u5bf9\u6027\u80fd\u7684\u5f71\u54cd<\/strong>\uff1aLINEs\u3001\u62f7\u8d1d\u6570\u53d8\u5f02\u548c\u5d4c\u5408\u53d8\u5f02\u5bf9\u6a21\u578b\u6027\u80fd\u7684\u5f71\u54cd\uff0c\u5f3a\u8c03\u4e86\u5728\u57fa\u56e0\u53d8\u5f02\u68c0\u6d4b\u4efb\u52a1\u4e2d\uff0c\u8003\u8651\u79fb\u52a8DNA\u5143\u4ef6\u548c\u53d8\u5f02\u7c7b\u578b\u7684\u5fc5\u8981\u6027\u3002\u8fd9\u4e9b\u672a\u88ab\u663e\u6027\u8bad\u7ec3\u7684\u6570\u636e\u7279\u6027\u53ef\u80fd\u662fDeepVariant\u5728\u53d8\u5f02\u68c0\u6d4b\u4efb\u52a1\u4e0a\u8d85\u8d8a\u5176\u4ed6\u5de5\u5177\u7684\u4e00\u4e2a\u91cd\u8981\u539f\u56e0\u3002<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">2. <strong>\u672a\u6765\u5de5\u4f5c<\/strong><\/h5>\n\n\n\n<p>\u7814\u7a76\u56e2\u961f\u5efa\u8bae\uff0c\u5176\u4ed6\u7528\u4e8eDNA\u5e8f\u5217\u5206\u6790\u7684\u673a\u5668\u5b66\u4e60\u6a21\u578b\u4e5f\u53ef\u4ee5\u91c7\u7528\u7c7b\u4f3c\u7684\u65b9\u6cd5\uff0c\u4ee5\u63ed\u793a\u6a21\u578b\u5728\u5904\u7406\u590d\u6742\u751f\u7269\u7cfb\u7edf\u65f6\u53ef\u80fd\u672a\u88ab\u8ba4\u8bc6\u5230\u7684\u7279\u6027\u3002\u6b64\u5916\uff0c\u8fd9\u9879\u5de5\u4f5c\u4e3a\u5982\u4f55\u63d0\u9ad8\u53d8\u5f02\u68c0\u6d4b\u5de5\u5177\u7684\u89e3\u91ca\u6027\u548c\u51c6\u786e\u6027\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5f88\u597d\u7684\u65b9\u5411\uff0c\u5373\u901a\u8fc7\u7406\u89e3\u6a21\u578b\u5185\u90e8\u7279\u5f81\u548c\u51b3\u7b56\u673a\u5236\u6765\u53d1\u73b0\u6539\u8fdb\u7684\u673a\u4f1a\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>DeepVariant on GitHub: <a href=\"https:\/\/github.com\/google\/deepvariant\">https:\/\/github.com\/google\/deepvariant<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DeepVariant\u662f\u7531Google\u7814\u7a76\u56e2\u961f\u5f00\u53d1\u7684\u4e00\u79cd\u57fa\u56e0\u53d8\u5f02\u68c0\u6d4b\u5de5\u5177\uff0c\u4e3b\u8981\u7528\u4e8e\u68c0\u6d4b\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u4e2d\u7684\u5c0f\u53d8\u5f02 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[8,36],"tags":[39,99,45,66],"class_list":["post-4934","post","type-post","status-publish","format-standard","hentry","category-tech","category-36","tag-ai","tag-health","tag-medicine","tag-google"],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"NullThought","author_link":"https:\/\/nullthought.net\/?author=1"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/nullthought.net\/?cat=8\" rel=\"category\">Tech<\/a> <a href=\"https:\/\/nullthought.net\/?cat=36\" 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