{"id":4819,"date":"2024-10-10T11:45:04","date_gmt":"2024-10-10T03:45:04","guid":{"rendered":"https:\/\/nullthought.net\/?p=4819"},"modified":"2025-02-23T11:09:46","modified_gmt":"2025-02-23T03:09:46","slug":"%e5%85%b3%e4%ba%8ealphafold%e7%9a%84%e8%af%a6%e7%bb%86%e4%bb%8b%e7%bb%8d","status":"publish","type":"post","link":"https:\/\/nullthought.net\/?p=4819","title":{"rendered":"\u5173\u4e8e\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u5386\u53f2\u548cAlphaFold\u7684\u8be6\u7ec6\u4ecb\u7ecd"},"content":{"rendered":"\n

Quanta<\/a><\/strong>\u6742\u5fd7\u4e8e2024\u5e746\u6708\u4efd\u53d1\u8868\u7684\u6587\u7ae0\u201cHow AI Revolutionized Protein Science, but Didn\u2019t End It<\/strong><\/a>\u201d\u5185\u5bb9\u975e\u5e38\u7cbe\u5f69\u3002\u6587\u7ae0\u4ecb\u7ecd\u4e86\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u5386\u53f2\u548cAlphaFold\uff0c\u9610\u8ff0\u4e86AlphaFold\u5728\u86cb\u767d\u8d28\u79d1\u5b66\u4e2d\u7684\u91cd\u8981\u6027\u4ee5\u53ca\u4eba\u5de5\u667a\u80fd\u5982\u4f55\u6539\u53d8\u79d1\u7814\u7684\u8303\u5f0f\uff0c\u5e76\u540c\u65f6\u5f3a\u8c03\u4e86\u5b9e\u9a8c\u9a8c\u8bc1\u7684\u4e0d\u53ef\u66ff\u4ee3\u6027\u3002\u8fd9\u4e00\u9769\u547d\u4e0d\u4ec5\u4e3a\u79d1\u5b66\u5bb6\u63d0\u4f9b\u4e86\u66f4\u5f3a\u6709\u529b\u7684\u5de5\u5177\uff0c\u4e5f\u4e3a\u751f\u7269\u79d1\u5b66\u7684\u672a\u6765\u53d1\u5c55\u63cf\u7ed8\u4e86\u4ee4\u4eba\u5174\u594b\u7684\u56fe\u666f\u3002\u6587\u7ae0\u4f5c\u8005\u4e3aYasemin Saplakoglu<\/a>\u3002<\/p>\n\n\n\n

AlphaFold\u7684\u4e3b\u8981\u53d1\u660e\u4ebaJohn Jumper\u5728Linkedin\u4e0a\u63a8\u8350\u4e86\u8fd9\u7bc7\u6587\u7ae0<\/a>\uff1a<\/p>\n\n\n\n

\n

Quanta wrote a really wonderful article on the history of protein structure prediction, and they captured great stories and quotes from scientists all around the field. It even includes a picture of me from my undergrad days looking like a “real” physicist. I would highly recommend it!
——
Quanta \u5199\u4e86\u4e00\u7bc7\u975e\u5e38\u7cbe\u5f69\u7684\u6587\u7ae0\uff0c\u8bb2\u8ff0\u4e86\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u7684\u5386\u53f2\uff0c\u5e76\u4e14\u8bb0\u5f55\u4e86\u6765\u81ea\u5404\u4e2a\u9886\u57df\u79d1\u5b66\u5bb6\u7684\u7cbe\u5f69\u6545\u4e8b\u548c\u5f15\u7528\u3002\u6587\u7ae0\u4e2d\u751a\u81f3\u8fd8\u5305\u62ec\u4e86\u4e00\u5f20\u6211\u672c\u79d1\u65f6\u671f\u7684\u7167\u7247\uff0c\u770b\u8d77\u6765\u50cf\u4e2a\u201c\u771f\u6b63\u201d\u7684\u7269\u7406\u5b66\u5bb6\u3002\u6211\u5f3a\u70c8\u63a8\u8350\u5927\u5bb6\u9605\u8bfb\uff01<\/p>\n<\/blockquote>\n\n\n\n

John Jumper\u548cDemis Hassabis\u83b7\u5f972024\u5e74\u5ea6\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956<\/a>\uff0c\u4ed6\u4eec\u56e0\u5728\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\uff08protein structure prediction\uff09\u65b9\u9762\u4f5c\u51fa\u7684\u8d21\u732e\u800c\u83b7\u5f97\u4e00\u534a\u7684\u5956\u91d1\uff0c\u5404\u81ea\u56db\u5206\u4e4b\u4e00\u3002\u5956\u91d1\u7684\u53e6\u4e00\u534a\u5f52\u5c5eDavid Baker\u3002David Baker\u56e0\u5728\u8ba1\u7b97\u86cb\u767d\u8d28\u8bbe\u8ba1\uff08computational protein design\uff09\u65b9\u9762\u7684\u8d21\u732e\u800c\u83b7\u5956\u3002\u4e09\u4f4d\u83b7\u5956\u8005\u7684\u76f8\u5173\u5de5\u4f5c\uff0c\u6587\u7ae0\u5747\u6709\u4ecb\u7ecd<\/strong>\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u6587\u7ae0\u201cHow AI Revolutionized Protein Science, but Didn\u2019t End It<\/strong><\/a>\u201d\u7684\u5185\u5bb9\u4ecb\u7ecd\u5982\u4e0b\uff1a<\/p>\n\n\n\n

1. \u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u7684\u5386\u53f2\u80cc\u666f<\/strong><\/h5>\n\n\n\n

\u86cb\u767d\u8d28\u662f\u751f\u547d\u4f53\u4e2d\u81f3\u5173\u91cd\u8981\u7684\u5206\u5b50\uff0c\u5b83\u4eec\u627f\u62c5\u7740\u4ece\u8fd0\u8f93\u6c27\u6c14\u5230\u50ac\u5316\u5316\u5b66\u53cd\u5e94\u7b49\u5404\u79cd\u751f\u547d\u529f\u80fd\u3002\u86cb\u767d\u8d28\u7684\u529f\u80fd\u53d6\u51b3\u4e8e\u5b83\u4eec\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u800c\u8fd9\u79cd\u7ed3\u6784\u662f\u7531\u6c28\u57fa\u9178\u5e8f\u5217\u81ea\u53d1\u6298\u53e0\u800c\u6210\u7684\u3002\u8fd9\u4e00\u6298\u53e0\u8fc7\u7a0b\uff0c\u5982\u4f55\u4ece\u4e00\u7ef4\u7684\u6c28\u57fa\u9178\u94fe\u5f62\u6210\u590d\u6742\u7684\u4e09\u7ef4\u7ed3\u6784\uff0c\u4e00\u76f4\u662f\u751f\u7269\u5b66\u4e2d\u7684\u6838\u5fc3\u95ee\u9898\uff0c\u88ab\u79f0\u4e3a\u201c\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u201d\u3002<\/p>\n\n\n\n

\u81ea1950\u5e74\u4ee3\u8d77\uff0c\u751f\u7269\u5b66\u5bb6\u4eec\u5c31\u5c1d\u8bd5\u7406\u89e3\u8fd9\u4e00\u95ee\u9898\u3002\u514b\u91cc\u65af\u8482\u5b89\u00b7\u5b89\u82ac\u68ee\uff08Christian Anfinsen\uff09\u7684\u5b9e\u9a8c\u8868\u660e\uff0c\u4e00\u6761\u6c28\u57fa\u9178\u94fe\u672c\u8eab\u5305\u542b\u4e86\u8db3\u591f\u7684\u4fe1\u606f\u53bb\u6307\u5f15\u86cb\u767d\u8d28\u7684\u6b63\u786e\u6298\u53e0\uff0c\u8fd9\u4e00\u5047\u8bf4\u540e\u6765\u88ab\u79f0\u4e3a\u201c\u5b89\u82ac\u68ee\u5047\u8bf4\u201d\u3002\u968f\u540e\uff0c\u79d1\u5b66\u5bb6\u4eec\u5728\u5b9e\u9a8c\u5ba4\u4e2d\uff0c\u901a\u8fc7X\u5c04\u7ebf\u6676\u4f53\u5b66\u548c\u5176\u4ed6\u65b9\u6cd5\uff0c\u9010\u6b65\u89e3\u6790\u4e86\u8d8a\u6765\u8d8a\u591a\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u5b9e\u9a8c\u624b\u6bb5\u975e\u5e38\u8017\u65f6\u8017\u529b\uff0c\u6bcf\u89e3\u6790\u4e00\u4e2a\u86cb\u767d\u8d28\u7ed3\u6784\u901a\u5e38\u9700\u8981\u6570\u5e74\u7684\u52aa\u529b\u3002<\/p>\n\n\n\n

2. CASP\u7ade\u8d5b\u548cAlphaFold\u7684\u51fa\u73b0<\/strong><\/h5>\n\n\n\n

\u4e3a\u63a8\u52a8\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u65b9\u6cd5\u7684\u8fdb\u6b65\uff0cCASP\u7ade\u8d5b\u5e94\u8fd0\u800c\u751f\u3002\u8be5\u7ade\u8d5b\u6bcf\u4e24\u5e74\u4e3e\u884c\u4e00\u6b21\uff0c\u6c47\u805a\u4e86\u6765\u81ea\u4e16\u754c\u5404\u5730\u7684\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6\uff0c\u65e8\u5728\u6bd4\u8f83\u5404\u79cd\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u65b9\u6cd5\u3002\u5728\u6700\u521d\u7684\u51e0\u5341\u5e74\u91cc\uff0cCASP\u7ade\u8d5b\u7684\u8fdb\u5c55\u975e\u5e38\u7f13\u6162\uff0c\u8ba1\u7b97\u65b9\u6cd5\u7684\u51c6\u786e\u5ea6\u4e00\u76f4\u505c\u6ede\u4e0d\u524d\u3002\u800cAlphaFold2\u7684\u5230\u6765\u5f7b\u5e95\u6539\u53d8\u4e86\u8fd9\u79cd\u5c40\u9762\u3002<\/p>\n\n\n\n

\u57282020\u5e74\uff0cAlphaFold2\u4ee5\u8d85\u8fc790%\u7684\u51c6\u786e\u7387\u5927\u5e45\u9886\u5148\u4e8e\u5176\u4ed6\u53c2\u8d5b\u8005\uff0c\u51e0\u4e4e\u89e3\u51b3\u4e86\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u4e2d\u7684\u7ed3\u6784\u9884\u6d4b\u90e8\u5206\u3002AlphaFold2\u91c7\u7528\u4e86\u4e00\u79cd\u5148\u8fdb\u7684\u6df1\u5ea6\u5b66\u4e60\u67b6\u6784\uff0c\u5373\u201c\u53d8\u6362\u5668\u7f51\u7edc\u201d\uff08transformer\uff09\uff0c\u5e76\u7ed3\u5408\u4e86\u5927\u91cf\u6765\u81ea\u86cb\u767d\u8d28\u6570\u636e\u5e93\uff08Protein Data Bank, PDB\uff09\u7684\u6570\u636e\u8fdb\u884c\u8bad\u7ec3\u3002\u8fd9\u4f7f\u5f97\u5b83\u80fd\u591f\u4ece\u6c28\u57fa\u9178\u5e8f\u5217\u4e2d\u51c6\u786e\u9884\u6d4b\u51fa\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u6b64\u524d\uff0c\u7814\u7a76\u8005\u4eec\u9700\u8981\u901a\u8fc7\u5b9e\u9a8c\u82b1\u8d39\u6570\u5e74\u624d\u80fd\u5f97\u5230\u7684\u7ed3\u6784\uff0c\u73b0\u5728\u501f\u52a9AlphaFold2\u53ef\u4ee5\u5728\u51e0\u5206\u949f\u5185\u83b7\u5f97\u3002<\/p>\n\n\n\n

AlphaFold2\u7684\u51fa\u73b0\u9707\u60ca\u4e86\u86cb\u767d\u8d28\u79d1\u5b66\u754c\u3002\u5f88\u591a\u7814\u7a76\u4eba\u5458\uff0c\u5982\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u7684\u7cfb\u7edf\u751f\u7269\u5b66\u5bb6\u7a46\u7f55\u9ed8\u5fb7\u00b7\u963f\u5c14\u5e93\u83b1\u5e0c\uff08Mohammed AlQuraishi\uff09\uff0c\u5728\u4f1a\u8bae\u4e0a\u542c\u5230\u7ed3\u679c\u65f6\u611f\u5230\u6781\u5ea6\u9707\u60ca\uff0c\u6709\u4e9b\u4eba\u751a\u81f3\u4e00\u5ea6\u6000\u7591\u81ea\u5df1\u7684\u804c\u4e1a\u751f\u6daf\u662f\u5426\u4f1a\u88abAI\u53d6\u4ee3\u3002\u7136\u800c\uff0cAlphaFold2\u4e0d\u4ec5\u89e3\u51b3\u4e86\u79d1\u5b66\u5bb6\u4eec\u82e6\u82e6\u8ffd\u6c42\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u9884\u6d4b\u95ee\u9898\uff0c\u8fd8\u4e3a\u751f\u7269\u79d1\u5b66\u9886\u57df\u6253\u5f00\u4e86\u65b0\u7684\u7814\u7a76\u89c6\u91ce\u3002<\/p>\n\n\n\n

3. AlphaFold2\u7684\u5de5\u4f5c\u539f\u7406\u4e0e\u7a81\u7834<\/strong><\/h5>\n\n\n\n

AlphaFold2\u7684\u6210\u529f\u6e90\u4e8e\u5176\u521b\u65b0\u7684\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u3002\u8be5\u7cfb\u7edf\u901a\u8fc7\u8bad\u7ec3\u4e00\u4e2a\u5377\u79ef\u795e\u7ecf\u7f51\u7edc\u6765\u9884\u6d4b\u86cb\u767d\u8d28\u76843D\u7ed3\u6784\uff0c\u5e76\u4f7f\u7528\u53d8\u6362\u5668\u7f51\u7edc\u8fdb\u4e00\u6b65\u4f18\u5316\u9884\u6d4b\u7ed3\u679c\u3002\u5728\u9884\u6d4b\u8fc7\u7a0b\u4e2d\uff0cAlphaFold2\u9996\u5148\u5229\u7528\u86cb\u767d\u8d28\u5e8f\u5217\u7684\u5171\u540c\u6f14\u5316\u4fe1\u606f\uff0c\u901a\u8fc7\u6bd4\u5bf9\u6570\u4ee5\u4e07\u8ba1\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u6765\u53d1\u73b0\u54ea\u4e9b\u6c28\u57fa\u9178\u4e4b\u95f4\u5b58\u5728\u76f8\u4e92\u4f5c\u7528\uff0c\u7136\u540e\u57fa\u4e8e\u8fd9\u4e9b\u4fe1\u606f\u6784\u5efa\u51fa\u86cb\u767d\u8d28\u7684\u4e09\u7ef4\u7ed3\u6784\u3002\u4e0e\u4ee5\u5f80\u7684\u8ba1\u7b97\u65b9\u6cd5\u76f8\u6bd4\uff0cAlphaFold2\u7684\u9884\u6d4b\u7cbe\u5ea6\u6781\u9ad8\uff0c\u5c24\u5176\u5728\u5904\u7406\u590d\u6742\u7684\u591a\u4e9a\u57fa\u86cb\u767d\u8d28\u65f6\uff0c\u8868\u73b0\u51fa\u8272\u3002<\/p>\n\n\n\n

AlphaFold2\u7684\u4e00\u4e2a\u5173\u952e\u7279\u6027\u662f\u5176\u201c\u4fe1\u5fc3\u8bc4\u5206\u201d\uff0c\u5373\u5728\u9884\u6d4b\u6bcf\u4e2a\u86cb\u767d\u8d28\u7ed3\u6784\u65f6\uff0c\u5b83\u540c\u65f6\u4f1a\u7ed9\u51fa\u5bf9\u9884\u6d4b\u7ed3\u679c\u7684\u7f6e\u4fe1\u5ea6\u3002\u8fd9\u79cd\u81ea\u8bc4\u4f30\u80fd\u529b\u4f7f\u5f97\u7814\u7a76\u4eba\u5458\u5728\u5e94\u7528AlphaFold2\u7684\u9884\u6d4b\u7ed3\u679c\u65f6\u80fd\u591f\u66f4\u6709\u4f9d\u636e\u5730\u5224\u65ad\u5176\u53ef\u4fe1\u5ea6\u3002<\/p>\n\n\n\n

4. \u5bf9\u86cb\u767d\u8d28\u79d1\u5b66\u7684\u5f71\u54cd\u4e0e\u5c40\u9650<\/strong><\/h5>\n\n\n\n

\u5c3d\u7ba1AlphaFold2\u7684\u6210\u529f\u65e0\u7591\u6539\u53d8\u4e86\u86cb\u767d\u8d28\u79d1\u5b66\u7684\u7814\u7a76\u65b9\u5f0f\uff0c\u4f46\u5b83\u5e76\u6ca1\u6709\u5f7b\u5e95\u6d88\u9664\u5b9e\u9a8c\u7814\u7a76\u7684\u5fc5\u8981\u6027\u3002AlphaFold2\u4e3b\u8981\u89e3\u51b3\u4e86\u9759\u6001\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u9884\u6d4b\u95ee\u9898\uff0c\u4f46\u5b83\u65e0\u6cd5\u6a21\u62df\u86cb\u767d\u8d28\u5728\u52a8\u6001\u73af\u5883\u4e2d\u7684\u884c\u4e3a\u3002\u4f8b\u5982\uff0c\u86cb\u767d\u8d28\u5728\u7ec6\u80de\u5185\u7684\u73af\u5883\u4e2d\u5f80\u5f80\u53d7\u5230\u5176\u4ed6\u5206\u5b50\u3001\u79bb\u5b50\u7b49\u7684\u5f71\u54cd\uff0c\u5176\u7ed3\u6784\u4f1a\u53d1\u751f\u53d8\u5316\u3002AlphaFold2\u65e0\u6cd5\u9884\u6d4b\u8fd9\u4e9b\u52a8\u6001\u53d8\u5316\uff0c\u4e5f\u65e0\u6cd5\u9884\u6d4b\u86cb\u767d\u8d28\u4e0e\u5176\u4ed6\u5206\u5b50\uff08\u5982DNA\u3001RNA\u6216\u5176\u4ed6\u86cb\u767d\u8d28\uff09\u5f62\u6210\u590d\u5408\u4f53\u65f6\u7684\u7cbe\u786e\u7ed3\u6784\u3002\u56e0\u6b64\uff0c\u79d1\u5b66\u5bb6\u4eec\u4f9d\u7136\u9700\u8981\u4f9d\u9760\u5b9e\u9a8c\u65b9\u6cd5\u6765\u9a8c\u8bc1AlphaFold2\u7684\u9884\u6d4b\uff0c\u5e76\u8865\u5145\u5b83\u65e0\u6cd5\u6db5\u76d6\u7684\u5185\u5bb9\u3002<\/p>\n\n\n\n

\u4f8b\u5982\uff0c\u4e00\u4e9b\u79d1\u5b66\u5bb6\u6307\u51fa\uff0cAlphaFold2\u5728\u9884\u6d4b\u86cb\u767d\u8d28\u590d\u5408\u7269\uff08\u591a\u4e2a\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff09\u65b9\u9762\uff0c\u51c6\u786e\u5ea6\u6709\u6240\u4e0b\u964d\u3002\u6b64\u5916\uff0c\u5bf9\u4e8e\u5b58\u5728\u591a\u79cd\u6784\u8c61\u7684\u86cb\u767d\u8d28\uff08\u5373\u201c\u6298\u53e0\u4ea4\u6362\u86cb\u767d\u201d\uff09\uff0cAlphaFold2\u4e5f\u672a\u80fd\u5f88\u597d\u5730\u9884\u6d4b\u5176\u5728\u4e0d\u540c\u73af\u5883\u4e2d\u7684\u4e0d\u540c\u5f62\u6001\u3002\u52a8\u6001\u86cb\u767d\u8d28\uff08\u5982\u672c\u8d28\u65e0\u5e8f\u86cb\u767d\uff0cintrinsically disordered proteins\uff09\u7684\u9884\u6d4b\u66f4\u662f\u56f0\u96be\uff0c\u56e0\u4e3a\u8fd9\u4e9b\u86cb\u767d\u8d28\u5728\u81ea\u7136\u72b6\u6001\u4e0b\u6ca1\u6709\u7a33\u5b9a\u7684\u7ed3\u6784\uff0c\u59cb\u7ec8\u5904\u4e8e\u4e0d\u65ad\u53d8\u5316\u4e4b\u4e2d\u3002<\/p>\n\n\n\n

5. AlphaFold3\u4e0e\u672a\u6765\u53d1\u5c55<\/strong><\/h5>\n\n\n\n

\u5728AlphaFold2\u53d6\u5f97\u5de8\u5927\u6210\u529f\u540e\uff0c\u8c37\u6b4cDeepMind\u5e76\u6ca1\u6709\u505c\u6b62\u4ed6\u4eec\u7684\u7814\u7a76\u6b65\u4f10\u3002\u57282024\u5e74\uff0cAlphaFold3\u53d1\u5e03\uff0c\u8fd9\u4e00\u7248\u672c\u5728\u9884\u6d4b\u86cb\u767d\u8d28\u4e0e\u5176\u4ed6\u751f\u7269\u5927\u5206\u5b50\uff08\u5982DNA\u3001RNA\u7b49\uff09\u76f8\u4e92\u4f5c\u7528\u65f6\u7684\u7ed3\u6784\u65b9\u9762\u505a\u51fa\u4e86\u91cd\u5927\u6539\u8fdb\u3002\u6b64\u5916\uff0cAlphaFold3\u80fd\u591f\u66f4\u51c6\u786e\u5730\u9884\u6d4b\u5305\u542b\u591a\u4e2a\u4e9a\u57fa\u7684\u590d\u5408\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u8fdb\u4e00\u6b65\u7f29\u5c0f\u4e86\u86cb\u767d\u8d28\u79d1\u5b66\u4e2d\u7684\u7a7a\u767d\u9886\u57df\u3002<\/p>\n\n\n\n

AlphaFold3\u91c7\u7528\u4e86\u66f4\u52a0\u590d\u6742\u7684\u53d8\u6362\u5668\u67b6\u6784\uff0c\u4f7f\u5f97\u5b83\u80fd\u591f\u66f4\u597d\u5730\u7406\u89e3\u86cb\u767d\u8d28\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u540c\u65f6\uff0cAlphaFold3\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u514b\u670d\u4e86AlphaFold2\u5728\u52a8\u6001\u86cb\u767d\u8d28\u9884\u6d4b\u65b9\u9762\u7684\u5c40\u9650\u6027\uff0c\u80fd\u591f\u66f4\u597d\u5730\u6a21\u62df\u86cb\u767d\u8d28\u5728\u4e0d\u540c\u73af\u5883\u4e2d\u7684\u5f62\u6001\u53d8\u5316\u3002<\/p>\n\n\n\n

\u4e0d\u8fc7\uff0c\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u4e0eAlphaFold2\u4e0d\u540c\uff0cAlphaFold3\u5e76\u672a\u5f00\u6e90\uff0c\u800c\u662f\u4f5c\u4e3a\u8c37\u6b4c\u7684\u5546\u4e1a\u79d8\u5bc6\u4fdd\u7559\u3002\u8fd9\u610f\u5473\u7740\u5b66\u672f\u754c\u548c\u5de5\u4e1a\u754c\u5728\u5e94\u7528AlphaFold3\u65f6\uff0c\u9762\u4e34\u7740\u66f4\u591a\u7684\u9650\u5236\u3002<\/p>\n\n\n\n

6. \u4eba\u5de5\u667a\u80fd\u5728\u86cb\u767d\u8d28\u8bbe\u8ba1\u4e2d\u7684\u5e94\u7528<\/strong><\/h5>\n\n\n\n

AlphaFold2\u7684\u6210\u529f\u4e5f\u5f15\u53d1\u4e86\u79d1\u5b66\u5bb6\u4eec\u5728\u86cb\u767d\u8d28\u8bbe\u8ba1\u9886\u57df\u7684\u63a2\u7d22\u70ed\u60c5\u3002\u534e\u76db\u987f\u5927\u5b66\u7684\u5927\u536b\u00b7\u8d1d\u514b\uff08David Baker\uff09\u7b49\u4eba\u4f7f\u7528\u57fa\u4e8eAlphaFold\u7684\u6280\u672f\u5f00\u53d1\u4e86RoseTTAFold\uff0c\u7528\u4e8e\u8bbe\u8ba1\u81ea\u7136\u754c\u4e2d\u4e0d\u5b58\u5728\u7684\u65b0\u578b\u86cb\u767d\u8d28\u3002\u8fd9\u4e00\u65b9\u5411\u88ab\u79f0\u4e3a\u201c\u9006\u5411\u86cb\u767d\u8d28\u6298\u53e0\u95ee\u9898\u201d\uff0c\u5373\u7ed9\u5b9a\u4e00\u4e2a\u7279\u5b9a\u7684\u86cb\u767d\u8d28\u7ed3\u6784\uff0c\u5229\u7528\u4eba\u5de5\u667a\u80fd\u6765\u8bbe\u8ba1\u53ef\u4ee5\u6298\u53e0\u6210\u8fd9\u79cd\u7ed3\u6784\u7684\u6c28\u57fa\u9178\u5e8f\u5217\u3002<\/p>\n\n\n\n

\u8fd9\u79cd\u86cb\u767d\u8d28\u8bbe\u8ba1\u65b9\u6cd5\u5bf9\u4e8e\u836f\u7269\u5f00\u53d1\u548c\u73af\u5883\u6cbb\u7406\u7b49\u5e94\u7528\u9886\u57df\u6709\u7740\u91cd\u8981\u7684\u610f\u4e49\u3002\u4f8b\u5982\uff0c\u79d1\u5b66\u5bb6\u4eec\u53ef\u4ee5\u8bbe\u8ba1\u51fa\u80fd\u591f\u5206\u89e3\u5851\u6599\u6c61\u67d3\u7684\u65b0\u578b\u9176\uff0c\u6216\u8005\u80fd\u591f\u9ad8\u6548\u6355\u83b7\u78b3\u7684\u86cb\u767d\u8d28\u7ed3\u6784\u3002\u8fd9\u79cd\u4ece\u5934\u8bbe\u8ba1\u86cb\u767d\u8d28\u7684\u65b9\u6cd5\u4f9d\u8d56\u4e8eAI\u5de5\u5177\u7684\u5feb\u901f\u8ba1\u7b97\u80fd\u529b\uff0c\u4f7f\u5f97\u539f\u672c\u9700\u8981\u6570\u5e74\u751a\u81f3\u6570\u5341\u5e74\u624d\u80fd\u5b9e\u73b0\u7684\u8bbe\u8ba1\u76ee\u6807\u5728\u51e0\u5929\u5185\u4fbf\u80fd\u5b8c\u6210\u3002<\/p>\n\n\n\n

7. \u5bf9\u4eba\u5de5\u667a\u80fd\u7684\u4fe1\u4efb\u4e0e\u53cd\u601d<\/strong><\/h5>\n\n\n\n

AlphaFold2\u7684\u6210\u529f\u4e0d\u4ec5\u6539\u53d8\u4e86\u86cb\u767d\u8d28\u79d1\u5b66\uff0c\u4e5f\u6539\u53d8\u4e86\u79d1\u5b66\u5bb6\u4eec\u5bf9\u4eba\u5de5\u667a\u80fd\u7684\u6001\u5ea6\u3002\u957f\u671f\u4ee5\u6765\uff0c\u8bb8\u591a\u5b9e\u9a8c\u751f\u7269\u5b66\u5bb6\u5bf9\u8ba1\u7b97\u65b9\u6cd5\u6301\u6000\u7591\u6001\u5ea6\uff0c\u8ba4\u4e3a\u8ba1\u7b97\u7ed3\u679c\u7f3a\u4e4f\u5b9e\u9a8c\u7684\u53ef\u9760\u6027\u3002\u7136\u800c\uff0cAlphaFold2\u4ee5\u5176\u9ad8\u7cbe\u5ea6\u7684\u9884\u6d4b\uff0c\u6539\u53d8\u4e86\u8fd9\u79cd\u770b\u6cd5\u3002\u5b9e\u9a8c\u751f\u7269\u5b66\u5bb6\u5f00\u59cb\u8ba4\u8bc6\u5230\uff0c\u4eba\u5de5\u667a\u80fd\u53ef\u4ee5\u6210\u4e3a\u4ed6\u4eec\u7684\u91cd\u8981\u5de5\u5177\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u7ade\u4e89\u5bf9\u624b\u3002<\/p>\n\n\n\n

\u7136\u800c\uff0c\u6b63\u5982\u4e00\u4e9b\u79d1\u5b66\u5bb6\u6240\u6307\u51fa\u7684\uff0cAlphaFold2\u7684\u9884\u6d4b\u7ed3\u679c\u867d\u7136\u7cbe\u786e\uff0c\u4f46\u5e76\u4e0d\u7b49\u540c\u4e8e\u5b9e\u9a8c\u9a8c\u8bc1\u3002\u8fc7\u5ea6\u4f9d\u8d56AI\u5de5\u5177\u7684\u98ce\u9669\u5728\u4e8e\uff0c\u67d0\u4e9b\u79d1\u5b66\u5bb6\u53ef\u80fd\u4f1a\u5ffd\u89c6\u5fc5\u8981\u7684\u5b9e\u9a8c\u9a8c\u8bc1\uff0c\u4ece\u800c\u8bef\u5bfc\u7814\u7a76\u65b9\u5411\u3002\u4f8b\u5982\uff0c\u6709\u4e9b\u7814\u7a76\u56e2\u961f\u5728\u6ca1\u6709\u5b9e\u9a8c\u9a8c\u8bc1\u7684\u60c5\u51b5\u4e0b\uff0c\u76f4\u63a5\u5c06AlphaFold2\u7684\u9884\u6d4b\u7ed3\u679c\u7528\u4e8e\u79d1\u7814\u8bba\u6587\u4e2d\uff0c\u5bfc\u81f4\u4e86\u9519\u8bef\u7684\u7ed3\u8bba\u3002\u56e0\u6b64\uff0c\u79d1\u5b66\u5bb6\u4eec\u5728\u4f7f\u7528AI\u5de5\u5177\u65f6\uff0c\u4ecd\u9700\u4fdd\u6301\u8db3\u591f\u7684\u8c28\u614e\u548c\u6279\u5224\u6027\u3002<\/p>\n\n\n\n

8. \u7ed3\u8bba<\/strong><\/h5>\n\n\n\n

\u7efc\u4e0a\u6240\u8ff0\uff0cAlphaFold2\u7684\u51fa\u73b0\u6807\u5fd7\u7740\u86cb\u767d\u8d28\u79d1\u5b66\u7684\u91cd\u5927\u8fdb\u6b65\uff0c\u5b83\u4e3a\u79d1\u5b66\u5bb6\u4eec\u63d0\u4f9b\u4e86\u4e00\u79cd\u5feb\u901f\u9884\u6d4b\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u65b0\u5de5\u5177\uff0c\u5927\u5927\u52a0\u901f\u4e86\u751f\u547d\u79d1\u5b66\u7684\u7814\u7a76\u8fdb\u7a0b\u3002\u7136\u800c\uff0cAI\u5de5\u5177\u5e76\u672a\u5b8c\u5168\u53d6\u4ee3\u5b9e\u9a8c\u624b\u6bb5\uff0c\u800c\u662f\u4e0e\u4e4b\u76f8\u8f85\u76f8\u6210\uff0c\u5171\u540c\u63a8\u52a8\u79d1\u5b66\u7684\u8fdb\u6b65\u3002\u672a\u6765\uff0c\u968f\u7740AlphaFold3\u7b49\u65b0\u5de5\u5177\u7684\u53d1\u5c55\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c06\u5728\u86cb\u767d\u8d28\u4e0e\u5176\u4ed6\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u3001\u86cb\u767d\u8d28\u8bbe\u8ba1\u7b49\u9886\u57df\u53d6\u5f97\u66f4\u591a\u7a81\u7834\u3002\u800cAI\u5728\u751f\u7269\u79d1\u5b66\u4e2d\u7684\u5e94\u7528\u4e5f\u5c06\u6108\u52a0\u5e7f\u6cdb\uff0c\u6210\u4e3a\u63a8\u52a8\u79d1\u5b66\u53d1\u73b0\u7684\u91cd\u8981\u529b\u91cf\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

Quanta\u6742\u5fd7\u4e8e2024\u5e746\u6708\u4efd\u53d1\u8868\u7684\u6587\u7ae0\u201cHow AI Revolutionized Protein Sc […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[8,36],"tags":[39,95,45],"class_list":["post-4819","post","type-post","status-publish","format-standard","hentry","category-tech","category-36","tag-ai","tag-transformer","tag-medicine"],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"NullThought","author_link":"https:\/\/nullthought.net\/?author=1"},"rttpg_comment":0,"rttpg_category":"Tech<\/a> \u79d1\u5b66<\/a>","rttpg_excerpt":"Quanta\u6742\u5fd7\u4e8e2024\u5e746\u6708\u4efd\u53d1\u8868\u7684\u6587\u7ae0\u201cHow AI Revolutionized Protein Sc…","_links":{"self":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts\/4819","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4819"}],"version-history":[{"count":4,"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts\/4819\/revisions"}],"predecessor-version":[{"id":4829,"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts\/4819\/revisions\/4829"}],"wp:attachment":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}