{"id":4567,"date":"2024-09-06T16:11:43","date_gmt":"2024-09-06T08:11:43","guid":{"rendered":"https:\/\/nullthought.net\/?p=4567"},"modified":"2025-03-20T14:04:37","modified_gmt":"2025-03-20T06:04:37","slug":"alphaproteo%e5%8f%af%e7%94%9f%e6%88%90%e6%96%b0%e5%9e%8b%e8%9b%8b%e7%99%bd%e8%b4%a8%e4%bb%a5%e7%94%a8%e4%ba%8e%e7%94%9f%e7%89%a9%e5%ad%a6%e5%92%8c%e5%81%a5%e5%ba%b7%e7%a0%94%e7%a9%b6","status":"publish","type":"post","link":"https:\/\/nullthought.net\/?p=4567","title":{"rendered":"AlphaProteo\u53ef\u751f\u6210\u65b0\u578b\u86cb\u767d\u8d28\u4ee5\u7528\u4e8e\u751f\u7269\u5b66\u548c\u5065\u5eb7\u7814\u7a76"},"content":{"rendered":"\n<p><a href=\"https:\/\/deepmind.google\/discover\/blog\/alphaproteo-generates-novel-proteins-for-biology-and-health-research\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>AlphaProteo<\/strong><\/a>\u7cfb\u7edf\u7531Google DeepMind\u5f00\u53d1\uff0c\u662f\u4e00\u79cd\u5229\u7528\u4eba\u5de5\u667a\u80fd\u8bbe\u8ba1\u65b0\u578b\u86cb\u767d\u8d28\u7ed3\u5408\u7269\u7684\u7cfb\u7edf\u3002AlphaProteo\u901a\u8fc7\u4eba\u5de5\u667a\u80fd\u8bbe\u8ba1\u65b0\u578b\u86cb\u767d\u8d28\u7ed3\u5408\u7269\uff0c\u8fd9\u4e00\u6280\u672f\u6709\u671b\u5f7b\u5e95\u6539\u53d8\u6211\u4eec\u5bf9\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u7406\u89e3\uff0c\u6781\u5927\u5730\u4fc3\u8fdb\u751f\u7269\u5b66\u548c\u5065\u5eb7\u9886\u57df\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u5305\u62ec\u836f\u7269\u53d1\u73b0\u3001\u75be\u75c5\u8bca\u65ad\u4ee5\u53ca\u519c\u4e1a\u4e2d\u7684\u5e94\u7528\u3002<\/p>\n\n\n\n<p><strong>AlphaProteo<\/strong>\u7cfb\u7edf\u80fd\u591f\u8bbe\u8ba1\u9ad8\u4eb2\u548c\u529b\u7684\u86cb\u767d\u8d28\u7ed3\u5408\u7269\u3002\u8be5\u7cfb\u7edf\u53ef\u4ee5\u521b\u5efa\u80fd\u591f\u6709\u6548\u7ed3\u5408\u7279\u5b9a\u5206\u5b50\u9776\u6807\u7684\u86cb\u767d\u8d28\uff0c\u4ece\u800c\u52a0\u6df1\u6211\u4eec\u5bf9\u751f\u7269\u5b66\u8fc7\u7a0b\u7684\u7406\u89e3\uff0c\u5e76\u5728\u836f\u7269\u53d1\u73b0\u3001\u751f\u7269\u4f20\u611f\u5668\u5f00\u53d1\u7b49\u65b9\u9762\u5177\u6709\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002\u5b83\u5df2\u5728\u591a\u79cd\u9776\u6807\u86cb\u767d\u8d28\u4e0a\u8fdb\u884c\u4e86\u6d4b\u8bd5\uff0c\u5305\u62ec\u4e0e\u764c\u75c7\u3001\u708e\u75c7\u3001\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u4ee5\u53ca\u75c5\u6bd2\u611f\u67d3\uff08\u4f8b\u5982SARS-CoV-2\u523a\u7a81\u86cb\u767d\uff09\u76f8\u5173\u7684\u86cb\u767d\u8d28\u3002AlphaProteo\u7684\u8868\u73b0\u4f18\u4e8e\u73b0\u6709\u7684\u65b9\u6cd5\uff0c\u7ed3\u5408\u4eb2\u548c\u529b\u63d0\u9ad8\u4e863\u5230300\u500d\u3002<\/p>\n\n\n\n<p><strong>AlphaProteo<\/strong> \u7684\u86cb\u767d\u8d28\u7ed3\u5408\u7269\u53ef\u4ee5\u5e7f\u6cdb\u5e94\u7528\u4e8e\u836f\u7269\u8bbe\u8ba1\u3001\u75be\u75c5\u7406\u89e3\u3001\u8bca\u65ad\u7b49\u9886\u57df\u3002\u8be5\u6280\u672f\u6709\u53ef\u80fd\u52a0\u901f\u65b0\u6cbb\u7597\u65b9\u6cd5\u7684\u5f00\u53d1\uff0c\u6539\u5584\u6210\u50cf\u6280\u672f\u548c\u8bca\u65ad\u5de5\u5177\uff0c\u8fd8\u53ef\u4ee5\u5728\u519c\u4e1a\u4e2d\u5e94\u7528\uff0c\u5982\u589e\u5f3a\u4f5c\u7269\u7684\u6297\u75c5\u80fd\u529b\u3002<\/p>\n\n\n\n<p><strong>AlphaProteo<\/strong> \u57fa\u4e8e\u5e9e\u5927\u7684\u6570\u636e\u96c6\u8fdb\u884c\u8bad\u7ec3\uff0c\u8fd9\u4e9b\u6570\u636e\u6765\u81ea\u86cb\u767d\u8d28\u6570\u636e\u5e93\uff08PDB\uff09\u4ee5\u53caAlphaFold\u7684\u9884\u6d4b\u7ed3\u6784\uff0c\u4f7f\u5176\u80fd\u591f\u5b66\u4e60\u5206\u5b50\u95f4\u5982\u4f55\u76f8\u4e92\u7ed3\u5408\u3002\u8fd9\u4f7f\u5f97\u7cfb\u7edf\u53ef\u4ee5\u9488\u5bf9\u7279\u5b9a\u9776\u6807\uff08\u5982\u4e0e\u764c\u75c7\u548c\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u76f8\u5173\u7684VEGF-A\uff09\u8bbe\u8ba1\u86cb\u767d\u8d28\u3002\u7cfb\u7edf\u7684\u8bbe\u8ba1\u4e0d\u4ec5\u5728\u8ba1\u7b97\u673a\u6a21\u62df\u4e2d\u83b7\u5f97\u4e86\u6210\u529f\uff0c\u8fd8\u5728\u5b9e\u9a8c\u4e2d\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002\u4f8b\u5982\uff0c\u5728\u6d4b\u8bd5\u75c5\u6bd2\u86cb\u767dBHRF1\u65f6\uff0cAlphaProteo\u8bbe\u8ba1\u7684\u5019\u9009\u86cb\u767d\u4e2d\u670988%\u5728\u5b9e\u9a8c\u4e2d\u6210\u529f\u7ed3\u5408\u3002<\/p>\n\n\n\n<p>\u5c3d\u7ba1<strong>AlphaProteo<\/strong> \u53d6\u5f97\u4e86\u663e\u8457\u6210\u679c\uff0c\u4f46\u5728\u9488\u5bf9\u4e0e\u81ea\u8eab\u514d\u75ab\u75be\u75c5\uff08\u5982\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff09\u76f8\u5173\u7684TNF\u0251\u86cb\u767d\u65f6\uff0c\u7cfb\u7edf\u672a\u80fd\u6210\u529f\u8bbe\u8ba1\u51fa\u6709\u6548\u7684\u7ed3\u5408\u7269\u3002\u8fd9\u8868\u660e\u7cfb\u7edf\u5728\u8bbe\u8ba1\u590d\u6742\u9776\u6807\u7684\u7ed3\u5408\u7269\u65f6\u4ecd\u7136\u9762\u4e34\u6311\u6218\u3002\u8bbe\u8ba1\u51fa\u9ad8\u4eb2\u548c\u529b\u7684\u7ed3\u5408\u7269\u53ea\u662f\u7814\u7a76\u7684\u7b2c\u4e00\u6b65\uff0c\u540e\u7eed\u4ecd\u9700\u514b\u670d\u8bb8\u591a\u751f\u7269\u5de5\u7a0b\u65b9\u9762\u7684\u96be\u9898\uff0c\u4ee5\u5c06\u8fd9\u4e9b\u86cb\u767d\u8d28\u7ed3\u5408\u7269\u7528\u4e8e\u5b9e\u9645\u5e94\u7528\u3002<\/p>\n\n\n\n<p><strong>Google DeepMind<\/strong> \u5f3a\u8c03\u4e86\u5728\u751f\u7269\u5b89\u5168\u65b9\u9762\u8fdb\u884c\u8d1f\u8d23\u4efb\u53d1\u5c55\u7684\u91cd\u8981\u6027\u3002\u4ed6\u4eec\u6b63\u5728\u4e0e\u5916\u90e8\u4e13\u5bb6\u5408\u4f5c\uff0c\u786e\u4fdd\u86cb\u767d\u8d28\u8bbe\u8ba1\u7684\u5b89\u5168\u548c\u4f26\u7406\u53d1\u5c55\u3002\u672a\u6765\u5c06\u4e0e\u79d1\u5b66\u754c\u8fdb\u4e00\u6b65\u5408\u4f5c\uff0c\u6539\u8fdb\u7cfb\u7edf\u5e76\u63a2\u7d22\u5176\u66f4\u5e7f\u6cdb\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n\n\n\n<p><strong>AlphaProteo<\/strong> \u7684\u672a\u6765\u53d1\u5c55\u8ba1\u5212\u5305\u62ec\u63d0\u9ad8\u7b97\u6cd5\u7684\u6210\u529f\u7387\u548c\u4eb2\u548c\u529b\uff0c\u6269\u5c55\u7cfb\u7edf\u53ef\u4ee5\u89e3\u51b3\u7684\u8bbe\u8ba1\u95ee\u9898\u8303\u56f4\u3002\u4ed6\u4eec\u8fd8\u5728\u63a2\u7d22\u8be5\u6280\u672f\u5728\u836f\u7269\u8bbe\u8ba1\u4e2d\u7684\u5e94\u7528\uff0c\u5e76\u4e0e\u591a\u4e2a\u5b66\u79d1\u7684\u7814\u7a76\u4eba\u5458\u5408\u4f5c\uff0c\u653b\u514b\u66f4\u590d\u6742\u7684\u86cb\u767d\u8d28\u8bbe\u8ba1\u6311\u6218\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>AlphaProteo\u7cfb\u7edf\u7531Google DeepMind\u5f00\u53d1\uff0c\u662f\u4e00\u79cd\u5229\u7528\u4eba\u5de5\u667a\u80fd\u8bbe\u8ba1\u65b0\u578b\u86cb\u767d\u8d28\u7ed3\u5408\u7269\u7684\u7cfb\u7edf\u3002 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[8,36],"tags":[39,99,45,66],"class_list":["post-4567","post","type-post","status-publish","format-standard","hentry","category-tech","category-36","tag-ai","tag-health","tag-medicine","tag-google"],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"NullThought","author_link":"https:\/\/nullthought.net\/?author=1"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/nullthought.net\/?cat=8\" rel=\"category\">Tech<\/a> <a href=\"https:\/\/nullthought.net\/?cat=36\" rel=\"category\">\u79d1\u5b66<\/a>","rttpg_excerpt":"AlphaProteo\u7cfb\u7edf\u7531Google DeepMind\u5f00\u53d1\uff0c\u662f\u4e00\u79cd\u5229\u7528\u4eba\u5de5\u667a\u80fd\u8bbe\u8ba1\u65b0\u578b\u86cb\u767d\u8d28\u7ed3\u5408\u7269\u7684\u7cfb\u7edf\u3002&hellip;","_links":{"self":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts\/4567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4567"}],"version-history":[{"count":1,"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts\/4567\/revisions"}],"predecessor-version":[{"id":4568,"href":"https:\/\/nullthought.net\/index.php?rest_route=\/wp\/v2\/posts\/4567\/revisions\/4568"}],"wp:attachment":[{"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nullthought.net\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}