{"id":4340,"date":"2024-08-16T17:56:03","date_gmt":"2024-08-16T09:56:03","guid":{"rendered":"https:\/\/nullthought.net\/?p=4340"},"modified":"2024-08-16T17:58:46","modified_gmt":"2024-08-16T09:58:46","slug":"%e5%88%a9%e7%94%a8%e5%88%86%e5%ad%90%e5%a4%8d%e7%94%9f%ef%bc%88molecular-de-extinction%ef%bc%89%e5%92%8c%e6%b7%b1%e5%ba%a6%e5%ad%a6%e4%b9%a0%e5%8f%91%e7%8e%b0%e6%8a%97%e7%94%9f%e7%b4%a0","status":"publish","type":"post","link":"https:\/\/nullthought.net\/?p=4340","title":{"rendered":"\u5229\u7528\u5206\u5b50\u590d\u751f\uff08Molecular De-extinction\uff09\u548c\u6df1\u5ea6\u5b66\u4e60\u7814\u53d1\u6297\u751f\u7d20"},"content":{"rendered":"\n<p>\u6839\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08WHO\uff09\u7684\u6570\u636e\uff0c\u6bcf\u5e74\u5168\u7403\u6709\u8d85\u8fc7125\u4e07\u4eba\u56e0\u5bf9\u6297\u751f\u7d20\u7b49\u836f\u7269\u514d\u75ab\u7684\u611f\u67d3\u800c\u6b7b\u4ea1\u3002\u52302050\u5e74\uff0c\u8fd9\u4e00\u6570\u5b57\u53ef\u80fd\u4f1a\u589e\u52a0\u52301000\u4e07\u4eba\u3002\u800c\u5728\u672a\u6765\u516d\u5e74\u5185\uff0c\u7ea62400\u4e07\u4eba\u53ef\u80fd\u4f1a\u56e0\u4e3a\u6cbb\u7597\u4f20\u67d3\u75c5\u7684\u9ad8\u6602\u8d39\u7528\u800c\u9677\u5165\u6781\u7aef\u8d2b\u56f0\u3002<\/p>\n\n\n\n<p>\u4f7f\u7528\u4eba\u5de5\u667a\u80fd\u7684\u7814\u7a76\u4eba\u5458\u6b63\u5728\u6316\u6398\u65e9\u5df2\u706d\u7edd\u7684\u7269\u79cd\uff0c\u5982\u731b\u72b8\u8c61\u548c\u5de8\u578b\u6811\u61d2\u7684DNA\uff0c\u5e0c\u671b\u627e\u5230\u53e4\u4ee3\u57fa\u56e0\u7ec4\u7684\u79d8\u5bc6\uff0c\u4ee5\u5e2e\u52a9\u5bf9\u6297\u5f53\u4eca\u6700\u5177\u611f\u67d3\u6027\u7684\u75c5\u539f\u4f53\u3002\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\uff08University of Pennsylvania\uff09\u7684\u6559\u6388Cesar de la Fuente\u535a\u58eb\u9886\u5bfc\u7740\u4e00\u4e2a\u7814\u7a76\u56e2\u961f\uff0c\u4ed6\u4eec\u5229\u7528\u4eba\u5de5\u667a\u80fd\u6765\u63a2\u6d4b\u706d\u7edd\u7684\u53f2\u524d\u751f\u7269\u7684DNA\uff0c\u5bfb\u627e\u5bf9\u6297\u5371\u9669\u7684\u8010\u836f\u6027\u5fae\u751f\u7269\u7684\u65b0\u89e3\u51b3\u65b9\u6848\u3002\u8fd9\u79cd\u6280\u672f\u88abde la Fuente\u535a\u58eb\u53ca\u5176\u56e2\u961f\u79f0\u4e3a\u201c\u5206\u5b50\u590d\u751f\uff08Molecular De-extinction\uff09\u201d\uff0c\u5e76\u57282024\u5e746\u6708\u53d1\u8868\u5728\u300a\u81ea\u7136\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u300b\u671f\u520a\u4e0a\u7684\u4e00\u7bc7\u8bba\u6587\uff08<strong><a href=\"https:\/\/www.nature.com\/articles\/s41551-024-01201-x\" target=\"_blank\" rel=\"noreferrer noopener\">Deep-learning-enabled antibiotic discovery through molecular de-extinction<\/a><\/strong>\uff09\u4e2d\u8fdb\u884c\u4e86\u8be6\u7ec6\u63cf\u8ff0\u3002<\/p>\n\n\n\n<p>\u8be5\u7814\u7a76\u89e3\u51b3\u4e86\u6297\u751f\u7d20\u8010\u836f\u6027\u8fd9\u4e00\u5173\u952e\u95ee\u9898\u3002\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u901a\u8fc7\u6df1\u5ea6\u5b66\u4e60\u65b9\u6cd5\u63a2\u7d22\u5df2\u706d\u7edd\u751f\u7269\u86cb\u767d\u8d28\u7ec4\uff08\u79f0\u4e3a\u201c\u706d\u7edd\u7ec4\u201d\uff09\u4ee5\u53d1\u73b0\u5177\u6709\u6f5c\u5728\u6297\u83cc\u7279\u6027\u7684\u80bd\u5e8f\u5217\u7684\u521b\u65b0\u65b9\u6cd5\uff0c\u8fd9\u4e9b\u80bd\u53ef\u80fd\u6709\u52a9\u4e8e\u5bf9\u6297\u8010\u836f\u6027\u75c5\u539f\u4f53\u3002<\/p>\n\n\n\n<p>\u8bba\u6587\u4f5c\u8005\u4e3aFangping Wan, Marcelo D. T. Torres, Jacqueline Peng\u548cCesar de la Fuente-Nunez\uff0c\u5747\u6765\u81ea\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"801\" height=\"776\" src=\"https:\/\/nullthought.net\/wp-content\/uploads\/2024\/08\/image-11.png\" alt=\"\" class=\"wp-image-4341\" srcset=\"https:\/\/nullthought.net\/wp-content\/uploads\/2024\/08\/image-11.png 801w, https:\/\/nullthought.net\/wp-content\/uploads\/2024\/08\/image-11-300x291.png 300w, https:\/\/nullthought.net\/wp-content\/uploads\/2024\/08\/image-11-768x744.png 768w\" sizes=\"auto, (max-width: 801px) 100vw, 801px\" \/><figcaption class=\"wp-element-caption\"><strong><a href=\"https:\/\/www.nature.com\/articles\/s41551-024-01201-x\" target=\"_blank\" rel=\"noreferrer noopener\">Deep-learning-enabled antibiotic discovery through molecular de-extinction<\/a><\/strong><\/figcaption><\/figure>\n\n\n\n<p>\u4ee5\u4e0b\u4e3a\u8bba\u6587\u5185\u5bb9\u6982\u8ff0\uff1a<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">\u4e00\u3001\u65b9\u6cd5\u8bba<\/h4>\n\n\n\n<h5 class=\"wp-block-heading\">1. <strong>\u5206\u5b50\u590d\u751f\uff1a<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5206\u5b50\u590d\u751f\u7684\u6982\u5ff5\u6d89\u53ca\u4ece\u5df2\u706d\u7edd\u751f\u7269\u4e2d\u590d\u6d3b\u5206\u5b50\uff0c\u4ee5\u5e94\u5bf9\u5f53\u524d\u7684\u751f\u7269\u533b\u5b66\u6311\u6218\u3002<\/li>\n\n\n\n<li>\u4f5c\u8005\u5229\u7528\u6df1\u5ea6\u5b66\u4e60\u6280\u672f\uff0c\u6316\u6398\u5df2\u706d\u7edd\u751f\u7269\u7684\u86cb\u767d\u8d28\u7ec4\uff0c\u5bfb\u627e\u5177\u6709\u6f5c\u5728\u6297\u83cc\u6d3b\u6027\u7684\u5e8f\u5217\u3002<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">2. <strong>\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b &#8211; APEX\uff1a<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u540d\u4e3aAPEX\u7684\u6df1\u5ea6\u5b66\u4e60\u6a21\u578b\uff0c\u8fd9\u662f\u4e00\u79cd\u591a\u4efb\u52a1\u5b66\u4e60\u67b6\u6784\uff0c\u65e8\u5728\u9884\u6d4b\u80bd\u7684\u6297\u83cc\u6d3b\u6027\u3002<\/li>\n\n\n\n<li>APEX\u4f7f\u7528\u6765\u81ea\u5185\u90e8\u6570\u636e\u96c6\u548c\u516c\u5171\u7684\u6297\u83cc\u80bd\u6d3b\u6027\u548c\u7ed3\u6784\u6570\u636e\u5e93\uff08DBAASP\uff09\u7684\u6570\u636e\u8fdb\u884c\u8bad\u7ec3\u3002<\/li>\n\n\n\n<li>\u8be5\u6a21\u578b\u4f7f\u7528\u7ed3\u5408\u4e86\u9012\u5f52\u548c\u6ce8\u610f\u529b\u673a\u5236\u7684\u7f16\u7801\u5668\u795e\u7ecf\u7f51\u7edc\uff0c\u4ece\u80bd\u5e8f\u5217\u4e2d\u63d0\u53d6\u9690\u85cf\u7279\u5f81\uff0c\u7136\u540e\u5c06\u8fd9\u4e9b\u7279\u5f81\u8f93\u5165\u5230\u4e24\u4e2a\u5168\u8fde\u63a5\u795e\u7ecf\u7f51\u7edc\uff08FCNN\uff09\u4e2d\uff0c\u4ee5\u9884\u6d4b\u6297\u83cc\u6d3b\u6027\u3002<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">3. <strong>\u706d\u7edd\u7ec4\u7684\u6316\u6398\uff1a<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u7814\u7a76\u6536\u96c6\u4e86208\u4e2a\u5df2\u706d\u7edd\u7269\u79cd\u768412,860\u4e2a\u86cb\u767d\u8d28\u5e8f\u5217\u3002\u7ecf\u8fc7\u7b5b\u9009\uff0c\u5269\u4e0b\u4e865,190\u4e2a\u86cb\u767d\u8d28\uff0c\u6700\u7ec8\u8bc6\u522b\u51fa10,311,899\u4e2a\u80bd\u5e8f\u5217\u3002<\/li>\n\n\n\n<li>\u4f7f\u7528APEX\u9884\u6d4b\u8fd9\u4e9b\u5e8f\u5217\u7684\u6297\u83cc\u6d3b\u6027\uff0c\u7ed3\u679c\u53d1\u73b0\u4e8637,176\u4e2a\u80bd\u88ab\u9884\u6d4b\u4e3a\u5177\u6709\u5e7f\u8c31\u6297\u83cc\u6d3b\u6027\uff0c\u5176\u4e2d11,035\u4e2a\u80bd\u5728\u73b0\u5b58\u751f\u7269\u4e2d\u672a\u53d1\u73b0\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u4e8c\u3001\u5b9e\u9a8c\u9a8c\u8bc1<\/h4>\n\n\n\n<p>\u4f5c\u8005\u5408\u6210\u4e8669\u4e2aAPEX\u9884\u6d4b\u7684\u80bd\uff0c\u5e76\u5bf9\u5176\u6297\u83cc\u6d3b\u6027\u8fdb\u884c\u4e86\u5b9e\u9a8c\u9a8c\u8bc1\u3002\u5173\u952e\u53d1\u73b0\u5305\u62ec\uff1a<\/p>\n\n\n\n<h5 class=\"wp-block-heading\">1. <strong>\u6297\u83cc\u6d3b\u6027\uff1a<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u8fd9\u4e9b\u80bd\u8868\u73b0\u51fa\u4e0d\u540c\u6c34\u5e73\u7684\u6297\u83cc\u6d3b\u6027\uff0c\u547d\u4e2d\u7387\u4e3a59%\uff0c\u5373\u8bc6\u522b\u51fa\u5177\u6709\u6d3b\u6027\u80bd\u7684\u6bd4\u4f8b\u3002<\/li>\n\n\n\n<li>\u7814\u7a76\u91cd\u70b9\u4ecb\u7ecd\u4e86\u51e0\u79cd\u5177\u6709\u663e\u8457\u6297\u83cc\u7279\u6027\u7684\u80bd\uff0c\u5305\u62ec\u6765\u81ea\u731b\u72b8\u8c61\u7684mammuthusin-2\u548c\u6765\u81ea\u53e4\u4ee3\u6d77\u725b\u7684hydrodamin-1\u3002<\/li>\n<\/ul>\n\n\n\n<h5 class=\"wp-block-heading\">2. <strong>\u4f5c\u7528\u673a\u5236\uff1a<\/strong><\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>\u5927\u591a\u6570\u80bd\u901a\u8fc7\u4f7f\u7ec6\u80de\u8d28\u819c\u53bb\u6781\u5316\u6765\u6740\u6b7b\u7ec6\u83cc\uff0c\u8fd9\u4e00\u673a\u5236\u4e0d\u540c\u4e8e\u5df2\u77e5\u7684\u6297\u83cc\u80bd\uff0c\u5b83\u4eec\u901a\u5e38\u9776\u5411\u5916\u819c\u3002<\/li>\n\n\n\n<li>\u7814\u7a76\u8fd8\u63a2\u8ba8\u4e86\u8fd9\u4e9b\u80bd\u7684\u7406\u5316\u6027\u8d28\uff0c\u6307\u51fa\u5b83\u4eec\u5728\u6c28\u57fa\u9178\u7ec4\u6210\u548c\u4e8c\u7ea7\u7ed3\u6784\u65b9\u9762\u4e0e\u73b0\u4ee3\u6297\u83cc\u80bd\u5b58\u5728\u5dee\u5f02\u3002<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">\u4e09\u3001\u4e3b\u8981\u7ed3\u679c\u4e0e\u610f\u4e49<\/h4>\n\n\n\n<p>\u7814\u7a76\u8868\u660e\uff0c\u6df1\u5ea6\u5b66\u4e60\u53ef\u4ee5\u6709\u6548\u5730\u6316\u6398\u5df2\u706d\u7edd\u751f\u7269\u7684\u86cb\u767d\u8d28\u7ec4\uff0c\u4ece\u800c\u53d1\u73b0\u65b0\u7684\u6297\u751f\u7d20\u5019\u9009\u8005\u3002\u8fd9\u4e9b\u80bd\u7684\u53d1\u73b0\u4e3a\u5f00\u53d1\u53ef\u80fd\u5bf9\u6297\u6297\u751f\u7d20\u8010\u836f\u6027\u7ec6\u83cc\u7684\u65b0\u578b\u6297\u751f\u7d20\u5f00\u8f9f\u4e86\u65b0\u7684\u9014\u5f84\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u6839\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\uff08WHO\uff09\u7684\u6570\u636e\uff0c\u6bcf\u5e74\u5168\u7403\u6709\u8d85\u8fc7125\u4e07\u4eba\u56e0\u5bf9\u6297\u751f\u7d20\u7b49\u836f\u7269\u514d\u75ab\u7684\u611f\u67d3\u800c\u6b7b\u4ea1\u3002\u52302050\u5e74\uff0c\u8fd9\u4e00 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[8,36],"tags":[39,45,60],"class_list":["post-4340","post","type-post","status-publish","format-standard","hentry","category-tech","category-36","tag-ai","tag-medicine","tag-60"],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"NullThought","author_link":"https:\/\/nullthought.net\/?author=1"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/nullthought.net\/?cat=8\" rel=\"category\">Tech<\/a> <a href=\"https:\/\/nullthought.net\/?cat=36\" 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